10514-70-2

Usage

Uses

Used in Agricultural Industry:
2H-1,4-Benzoxazin-3(4H)-one, 2,2-dimethylis used as a natural defense chemical for its antifungal, antibacterial, and insecticidal properties, contributing to plant protection against pests and diseases.
Used in Pharmaceutical Industry:
2H-1,4-Benzoxazin-3(4H)-one, 2,2-dimethylis used for its bioactive properties, indicating potential applications in drug development and therapeutic treatments.
Used in Plant Biotechnology:
2H-1,4-Benzoxazin-3(4H)-one, 2,2-dimethylis utilized in the field of plant biotechnology to enhance crop protection and improve resistance against various biotic stresses.

Upstream product

• 129339-29-3 2-bromo-N-(2-hydroxyphenyl)-2-methylpropanamide 
• 88-75-5 2-hydroxynitrobenzene 
• 600-00-0 ethyl 2-bromoisobutyrate 
• 95-55-6 2-amino-phenol 
• 139-02-6 sodium phenoxide 
• 18672-04-3 ethyl 2-methyl-2-phenoxypropanoate 
• 943-45-3 2-methyl-2-phenoxypropionic acid 
• 344438-62-6 2-methyl-2-(2-nitrophenoxy)propionic acid ethyl ester 
• 20769-85-1 2-bromoisobutyric acid bromide 
• 10514-62-2 2-Methyl-2-(2-nitrophenoxy)propanoic Acid 

Downstream Products

• 866089-28-3 2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazine 

Relevant academic research and scientific papers

PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS

The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

NEW PHENYLAZETIDINECARBOXYLATE OR -CARBOXAMIDE COMPOUNDS

The invention relates to compounds of formula (I). where R, R1, R2, n, A and Cy have the meanings indicated in the description. The compounds of formula (I) are Nurr-1 modulators.

Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose) polymerase inhibitors

Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.

GLYCOSIDE DERIVATIVE AND USES THEREOF

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

GLYCOSIDE DERIVATIVE AND USES THEREOF

This invention relates to compounds represented by formula (I) wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

GLYCOSIDE DERIVATIVES AND USES THEREOF

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment

Glycoside Derivatives and Uses Thereof

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

[Omim][BF4], a green and recyclable ionic liquid medium for the one-pot chemoselective synthesis of benzoxazinones

An efficient procedure for the one-pot chemoselective synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives from their corresponding o-aminophenols is developed using DBU in the ionic liquid [omim][BF4]. Upon completion of the reaction and separation of the product, the ionic liquid is recovered and successfully reused over nine recycles without any noticeable loss of performance.

Carboxylic Acid Compounds and Use Thereof

Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: [image] wherein each symbol is as defined in the specification.

Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions

The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.