3-BroMo-5-fluorobenzene-1-sulfonyl chloride

Base Information

• Chemical Name: 3-BroMo-5-fluorobenzene-1-sulfonyl chloride
• CAS No.: 1214342-44-5
• Molecular Formula: C6H3BrClFO2S
• Molecular Weight: 273.51
• Hs Code.: 2909309090
• Mol file: 1214342-44-5.mol

Synonyms:3-BroMo-5-fluorobenzene-1-sulfonyl chloride;3-Bromo-5-fluorobenzenesulfonyl chloride

Chemical Property of 3-BroMo-5-fluorobenzene-1-sulfonyl chloride

Chemical Property:

• Boiling Point: 301.9±27.0 °C(Predicted)
• PSA: 42.52000
• Density: 1.867±0.06 g/cm3(Predicted)
• LogP: 3.59650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-fluorobenzene-1-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-5-fluorobenzene-1-sulfonyl Chloride was a useful reactant in preparation of tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg and HBV DNA production for the treatment of hepatitis B virus infections.

Technology Process of 3-BroMo-5-fluorobenzene-1-sulfonyl chloride

There total 4 articles about 3-BroMo-5-fluorobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

bis(pinacol)diborane (73183-34-3) + 3-bromo-5-fluoroaniline (134168-97-1) → 3-bromo-5-fluorobenzene-1-sulfonyl chloride (1214342-44-5)

Guidance literature:

3-bromo-5-fluoroaniline; With hydrogenchloride; sodium nitrite; In acetic acid; at 0 ℃; for 0.333333h; Cooling with ice;

bis(pinacol)diborane; With sodium hydrogensulfite; copper dichloride; In acetic acid; at 20 ℃; for 2.5h;

Reference yield:

benzyl 3-bromo-5-fluorophenyl sulphide → 3-bromo-5-fluorobenzene-1-sulfonyl chloride (1214342-44-5)

Guidance literature:

With hydrogenchloride; N-chloro-succinimide; In water; acetonitrile; at 0 - 20 ℃; for 2h;

Reference yield:

3-bromo-5-fluoroaniline (134168-97-1) → 3-bromo-5-fluorobenzene-1-sulfonyl chloride (1214342-44-5)

Guidance literature:

3-bromo-5-fluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 5 ℃;

With sulfur dioxide; acetic acid; copper(l) chloride; In water; at 20 ℃; for 2h;

DOI:10.1021/ml2000627

upstream raw materials:

3-bromo-5-fluoroaniline

bis(pinacol)diborane

1,3-dibromo-5-fluorobenzene