134168-97-1

Basic information

• Product Name: 3-Fluoro-5-bromoaniline
• Synonyms: 3-Fluoro-5-bromoaniline;5-BroMo-3-fluoroaniline;3-Bromo-5-fluoroaniline 97%;3-BroMo-5-fluoro-phenylaMine;Benzenamine, 3-bromo-5-fluoro-
• CAS NO: 134168-97-1
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.0130032
• Mol File: 134168-97-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 246℃
• Flash Point: 102℃
• Appearance: Brown/Liquid
• Density: 1.694
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.51±0.10(Predicted)
• CAS DataBase Reference: 3-Fluoro-5-bromoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-5-bromoaniline(134168-97-1)
• EPA Substance Registry System: 3-Fluoro-5-bromoaniline(134168-97-1)

Safety Data

• RIDADR: UN2811
• HazardClass: 6.1
• Hazardous Substances Data: 134168-97-1(Hazardous Substances Data)

Usage

General Description

3-Fluoro-5-bromoaniline is a specific type of organic compound that is part of the aniline and halobenzene groups. The systematic name of this chemical is exactly how it sounds - an aniline compound where the hydrogen atom on the 3rd carbon is replaced by a fluorine atom and the hydrogen on the 5th carbon is replaced by a bromine atom. This chemical oftentimes appears as a clear, colorless liquid and has a chemical formula of C6H5BrFN. Commonly, it's used in the manufacturing of other chemical products such as pharmaceuticals or dyes. It's important to note that considering its synthetic nature, it should be handled with care as it could potentially be toxic or harmful if mishandled.

Upstream product

• 7087-65-2 1-bromo-3-fluoro-5-nitrobenzene 
• 7439-89-6 iron 
• 10472-88-5 4-fluoro-2-bromo-6-nitroaniline 
• 364-78-3 2-nitro-4-fluoroaniline 
• 1435-51-4 1,3-dibromo-5-fluorobenzene 
• 807620-95-7 N-(3-bromo-5-fluorophenyl)acetamide 

Downstream Products

• 807620-96-8 2-[2-(3-bromo-5-fluoro-phenyl)-2H-tetrazol-5-yl]-pyridine 
• 1332626-18-2 N,N-diallyl-3-bromo-5-fluoroaniline 
• 1129541-62-3 4-(3-bromo-5-fluorophenyl)morpholine 
• 134168-96-0 N-(3-bromo-5-fluorophenyl)-N'-t-pentylthiourea 
• 134169-10-1 N-(3-bromo-5-fluorophenyl)-N'-t-pentylcarbodiimide 
• 807620-97-9 2-{2-[3-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-2H-tetrazol-5-yl}-pyridine 
• 1026951-54-1 3-[4-(3-bromo-5-fluoro-phenyl)-piperazin-1-yl]-1-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one 
• 507269-27-4 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile 

Relevant articles and documents

NOVEL COMPOUND FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME

Provided are a compound for an organic light emitting device and an organic light emitting device comprising the same. To this end, it is possible to provide a compound for an organic light emitting device which can be used as a host, a hole-transport material, or an electron-transport material capable of enhancing light-emitting efficiency of phosphorescent light-emitting materials by having outstanding electrical stability, an electron and hole transportability, and a high level of triplet state energy, and the organic light emitting device.

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

Structure-activity relationship studies on the phenyl ring of 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile 2 led to the discovery that small, non-hydrogen bond donor substituents at the 3-position led to a substantial increase in in vitro potency. In particular, 3-fluoro-5-(5-pyridin- 2-yl-2H-tetrazol-2-yl)benzonitrile (7) is a highly potent and selective mGlu5 receptor antagonist with good rat pharmacokinetics, brain penetration, and in vivo receptor occupancy.

Biologically selective potassium channel openers having 1,1- diethylpropyl group

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.