3-Methyl-3-Pyrrolidinol hydrochloride

Base Information

• Chemical Name: 3-Methyl-3-Pyrrolidinol hydrochloride
• CAS No.: 921592-91-8
• Molecular Formula: C5H12ClNO
• Molecular Weight: 137.609
• Hs Code.: 2933990090
• Mol file: 921592-91-8.mol

Synonyms:3-Methyl-3-Pyrrolidinol hydrochloride;3-Methyl-3-pyrrolidinol HCl

Chemical Property of 3-Methyl-3-Pyrrolidinol hydrochloride

Chemical Property:

• PSA: 32.26000
• LogP: 0.86150
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methylpyrrolidin-3-olHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methyl-3-Pyrrolidinol hydrochloride

There total 3 articles about 3-Methyl-3-Pyrrolidinol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

rac-tert-butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate (412278-02-5) → 3-methylpyrrolidin-3-ol monohydrochloride (921592-91-8,1956435-14-5,1956436-45-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h;

Reference yield: 100.0%

1-benzyl-3-methylpyrrolidin-3-ol (96567-93-0) → 3-methylpyrrolidin-3-ol monohydrochloride (921592-91-8,1956435-14-5,1956436-45-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium diacetate; In methanol; water; for 2h;

Reference yield: 20.0%

methyl magnesium iodide (917-64-6) + 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) → 3-methylpyrrolidin-3-ol monohydrochloride (921592-91-8,1956435-14-5,1956436-45-5)

Guidance literature:

methyl magnesium iodide; 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; diethyl ether; water; at -20 ℃; for 3h;

With hydrogenchloride; In 1,4-dioxane;

upstream raw materials:

rac-tert-butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate

1-benzyl-3-methylpyrrolidin-3-ol

methyl magnesium iodide

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

1-(3-hydroxy-3-methylpyrrolidin-1-yl)-3,3-diphenylpropyl-1-one

3-methyl-1-phenylethylpyrrolidin-3-ol

1-(diphenylmethyl)-3-methylpyrrolidin-3-ol

1-(3,5-difluorobenzyl)-3-methylpyrrolidin-3-ol

Refernces

• 1、 -. "1,4-DIHYDROPYRIDINE -3,5-DICARBOXYLATE DERIVATIVES, PREPARATION METHODS AND USES THEREOF". Paragraph 0121; 0122. . Retrieved 2014/03/25.
• 2、 -. "Antibacterial Compounds". Paragraph 0514. . Retrieved 2013/10/07.