1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone

Base Information

• Chemical Name: 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone
• CAS No.: 1378387-81-5
• Molecular Formula: C15H8BrClF2O
• Molecular Weight: 357.5772264
• Mol file: 1378387-81-5.mol

Synonyms:1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone;Ethanone, 1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-;7-Bromo-2-(chloroacetyl)-9,9-difluorofluorene

Chemical Property of 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone

Chemical Property:

• Melting Point: 183.0 to 187.0 °C
• Boiling Point: 428.5±45.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.69±0.1 g/cm3(Predicted)
• LogP: 4.99110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(7-Bromo-9,9-Difluoro-9h-Fluoren-2-Yl)-2-Chloro-Ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone

There total 24 articles about 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

C17H12BrClF2O2 → 1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone (1378387-81-5)

Guidance literature:

With perchloric acid; In dichloromethane; at 40 ℃; for 6h; Reagent/catalyst; Temperature;

Reference yield: 81.7%

C15H9BrF2O → 1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone (1378387-81-5)

Guidance literature:

With sulfuryl dichloride; In acetonitrile; at 30 - 35 ℃;

Reference yield: 79.1%

C18H14BrClF2O2 → 1-(7-bromo-9,9-difluoro-9-hydrofluoren-2-yl)-2-chloroethanone (1378387-81-5)

Guidance literature:

With perchloric acid; In dichloromethane; at 40 ℃; for 4h;

upstream raw materials:

2-bromo-9H-fluorene

2-bromo-7-iodofluorene

2-chloro-N-methoxy-N-methylacetamide

2-bromofluoren-9-one

Downstream raw materials:

(S)-6-(2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl) 5-tert-butyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate

3-[6-(9,9-difluoro-7-{2-[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2.4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-yl)-1H-benzoimidazol-2-yl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

6-[5-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-aza-spiro[2.4]heptane-5-carboxylic acid benzyl ester

5-aza-spiro[2.4]heptane-5,6-dicarboxylic acid 5-benzyl ester 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl] ester