3-Cyclopropyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Base Information

Chemical Name:3-Cyclopropyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one
CAS No.:380605-23-2
Molecular Formula:C9H9N3O
Molecular Weight:175.18726
Hs Code.:2933990090
DSSTox Substance ID:DTXSID30590126
Wikidata:Q82483804
Mol file:380605-23-2.mol

Synonyms:380605-23-2;3-Cyclopropyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one;3-Cyclopropyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;3-CYCLOPROPYL-1H-IMIDAZO[4,5-B]PYRIDIN-2-ONE;3-cyclopropyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;SCHEMBL16695655;DTXSID30590126;GS3937;AKOS006293621;NCGC00476491-01;F1907-1680

Suppliers and Price of 3-Cyclopropyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-Cyclopropyl-1H-imidazo[4,5-b]pyridin-2(3H)-one 95+%
1g
$ 880.00

Chemenu
3-cyclopropyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one 95%
1g
$ 830.00

Alichem
3-Cyclopropyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
1g
$ 714.00

Total 3 raw suppliers

Chemical Property of 3-Cyclopropyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Chemical Property:

PSA：50.68000
Density:1.433g/cm³
LogP:1.05950
Storage Temp.:2-8°C
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:175.074561919
Heavy Atom Count:13
Complexity:239

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

3-Cyclopropyl-1H-imidazo[4,5-b]pyridin-2(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1N2C3=C(C=CC=N3)NC2=O

Technology Process of 3-Cyclopropyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

There total 5 articles about 3-Cyclopropyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290313-23-4
N2-cyclopropylpyridine-2,3-diamine

: 530-62-1
1,1'-carbonyldiimidazole

: 380605-23-2
C₉H₉N₃O

Guidance literature:: In tetrahydrofuran; for 2.5h; Heating / reflux;

Reference yield:

: 6298-19-7
2-chloro-3-aminopyridine

: 380605-23-2
C₉H₉N₃O

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 0.17 h / -10 °C

1.2: 81 percent / tetrahydrofuran / 0.5 h

2.1: t-BuONa; XantPhos / Pd₂(dba)3 / Heating

With sodium hexamethyldisilazane; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran;
DOI:10.1055/s-2006-947355

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 380605-23-2
C₉H₉N₃O

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 18 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / ethanol

3: tetrahydrofuran / 2.5 h / Heating / reflux

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; acetonitrile;