5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester
• CAS No.: 1240949-59-0
• Molecular Formula: C₁₂H₁₀FNO₂
• Molecular Weight: 219.215
• Mol file: 1240949-59-0.mol

Synonyms:5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester

Chemical Property of 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester

There total 1 articles about 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.5%

C12H12FNO3 → methyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate (1240949-59-0)

Guidance literature:

With acetic acid; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 95.8%

Pyridine-3-sulfonyl chloride (16133-25-8) + methyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate (1240949-59-0) → C17H13FN2O4S

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield: 95.5%

methyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate (1240949-59-0) → 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid

Guidance literature:

With sodium hydroxide; In ethanol; water; at 70 ℃; for 3h;

Downstream raw materials:

1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt