(x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S

Base Information

• Chemical Name: (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S
• CAS No.: 2098974-13-9
• Molecular Formula: (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S
• Mol file: 2098974-13-9.mol

Synonyms:

Chemical Property of (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S

There total 56 articles about (x)C₄H₄O₄*C₁₇H₁₆FN₃O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

5-(2-fluorophenyl)-3-bromomethyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole + methylamine (74-89-5) + 2-butenedioic acid (6915-18-0,26099-09-2) → 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (2098974-13-9,881681-01-2)

Guidance literature:

5-(2-fluorophenyl)-3-bromomethyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrole; methylamine; With triethylamine; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; In toluene; at 25 ℃; for 4h;

2-butenedioic acid; In N,N-dimethyl-formamide; at 40 ℃; for 2h; Reagent/catalyst;

Reference yield: 90.2%

5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile (1807642-39-2) + methylamine hydrochloride (593-51-1) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt (2098974-13-9,881681-01-2)

Guidance literature:

5-(2-fluorophenyl)-1-(pyridin-3-yl-sulfonyl)-1H-pyrrole-3-carbonitrile; methylamine hydrochloride; With phosgene; sodium tetrahydroborate; bis[2-(di-tert-butylphosphino)ethyl]amine; sodium hydroxide; In tetrahydrofuran; for 10h; Inert atmosphere; Reflux;

(2E)-but-2-enedioic acid; at 20 ℃; for 1h; Solvent; Reagent/catalyst;

Reference yield: 90.0%

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine (881681-00-1) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrole-3-yl]-N-methylmethylamine fumaric acid salt (2098974-13-9,881681-01-2)

Guidance literature:

In methanol; at 25 - 50 ℃; for 0.5h; Temperature;

upstream raw materials:

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine

(2E)-but-2-enedioic acid

5‐(2-fluorophenyl)‐1‐(pyridine-3-sulfonyl)-1H-pyrrole-3-carbaldehyde

methylamine methanol

Downstream raw materials:

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-yl)-N-methylmethanamine