2-Bromoquinazoline

Base Information

• Chemical Name: 2-Bromoquinazoline
• CAS No.: 1316275-31-6
• Molecular Formula: C8H5BrN2
• Molecular Weight: 209.0427
• Mol file: 1316275-31-6.mol

Synonyms:2-Bromoquinazoline

Chemical Property of 2-Bromoquinazoline

Chemical Property:

• Boiling Point: 351.5±25.0 °C(Predicted)
• PKA: 0.17±0.30(Predicted)
• PSA: 25.78000
• Density: 1.656±0.06 g/cm3(Predicted)
• LogP: 2.39230
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromoquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromoquinazoline is a useful reagent in the preparation of triphenylene-?based polycyclic aromatic hydrocarbons (PAHs) from ring-?fused benzocyclobutenols (RBCBs) via the cleavage of the C-?C σ-?bond.

Technology Process of 2-Bromoquinazoline

There total 2 articles about 2-Bromoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

quinazoline 1-oxide (54145-20-9) → 2-bromoquinazoline, (1316275-31-6)

Guidance literature:

With N,N-dimethyl-formamide; phosphorus(V) oxybromide; In dichloromethane; at 0 - 25 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2016.07.083

Reference yield:

→ 2-bromoquinazoline, (1316275-31-6) + 5-bromo-2,6-dimethyl-3H-quinazolin-4-one (147149-87-9)

Guidance literature:

Reference yield: 82.0%

2-bromoquinazoline, (1316275-31-6) + 7,8-Benzobicyclo[4.2.0]okt-7-en-1-ol (31274-15-4) → 2-(2-(quinazolin-2-yl)phenyl)cyclohexanone

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; tricyclohexylphosphine; In toluene; at 85 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.joc.7b01727

upstream raw materials:

quinazoline 1-oxide

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