Pregna-1,4,6-triene-3,20-dione

Base Information

• Chemical Name: Pregna-1,4,6-triene-3,20-dione
• CAS No.: 4192-93-2
• Molecular Formula: C₂₁H₂₆O₂
• Molecular Weight: 310.436
• Mol file: 4192-93-2.mol

Synonyms:Pregna-1,4,6-triene-3,20-dione

Chemical Property of Pregna-1,4,6-triene-3,20-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pregna-1,4,6-triene-3,20-dione

There total 9 articles about Pregna-1,4,6-triene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Pregnenolone (145-13-1) → Pregna-1,4,6-triene-3,20-dione (4192-93-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 4h; Reflux; Inert atmosphere;

DOI:10.3390/molecules14114655

Reference yield: 5.7%

2,6-dibromoprogesterone (137493-29-9) → Pregna-1,4,6-triene-3,20-dione (4192-93-2) + 6-bromo-Δ6-progesterone (15251-02-2)

Guidance literature:

With lutidine; for 0.5h; Heating;

Reference yield:

Progesterone (57-83-0) → Pregna-1,4,6-triene-3,20-dione (4192-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr, Br₂, AcOH / diethyl ether / Ambient temperature

2: 37 percent / lutidine / 0.5 h / Heating

With lutidine; hydrogen bromide; bromine; acetic acid; In diethyl ether;

upstream raw materials:

2,6-dibromoprogesterone

2,6,17-tribromoprogesterone

Progesterone

Pregnenolone

Refernces

• 1、 Kim, Sujeong,Ma, Eunsook. "Synthesis of pregnane derivatives, their cytotoxicity on LNCaP and PC-3 cells, and screening on 5α-reductase inhibitory activity". experimental part. p. 4655 - 4668. Retrieved 2010/04/06.