Ethyl 6-amino-5-chloronicotinate

Base Information

• Chemical Name: Ethyl 6-amino-5-chloronicotinate
• CAS No.: 305329-79-7
• Molecular Formula: C₈H₉ClN₂O₂
• Molecular Weight: 200.625
• Hs Code.: 2933399090
• Mol file: 305329-79-7.mol

Synonyms:Ethyl 6-amino-5-chloronicotinate;6-AMino-5-chloro-nicotinic acid ethyl ester;3-PYRIDINECARBOXYLIC ACID, 6-AMINO-5-CHLORO-, ETHYL ESTER

Chemical Property of Ethyl 6-amino-5-chloronicotinate

Chemical Property:

• Boiling Point: 324.6±37.0 °C(Predicted)
• PKA: 2.12±0.49(Predicted)
• PSA: 65.21000
• Density: 1.326±0.06 g/cm3(Predicted)
• LogP: 2.07510

Purity/Quality:

99%, ^*data from raw suppliers

6-Amino-5-chloro-nicotinicAcidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 6-amino-5-chloronicotinate

There total 2 articles about Ethyl 6-amino-5-chloronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl-6-amino-nicotinate (39658-41-8) → 6-amino-5-chloronicotinic acid ethyl ester (305329-79-7)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; for 2h; Heating;

DOI:10.1016/j.bmc.2003.12.039

Reference yield:

6-aminonicotinic acid (3167-49-5) → 6-amino-5-chloronicotinic acid ethyl ester (305329-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: SOCl₂ / 72 h / Heating

1.2: 97 percent / NaOH / methanol / 1 h

2.1: 79 percent / N-chlorosuccinimide / acetonitrile / 2 h / Heating

With N-chloro-succinimide; thionyl chloride; In acetonitrile;

DOI:10.1016/j.bmc.2003.12.039

upstream raw materials:

ethyl-6-amino-nicotinate

6-aminonicotinic acid

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