Suvorexant intermediate

Base Information

Chemical Name:Suvorexant intermediate
CAS No.:1620097-07-5
Molecular Formula:C23H27N5O
Molecular Weight:389.49
Hs Code.:

Synonyms:(R)-(4-Benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;[(7R)-Hexahydro-7-methyl-4-(phenylmethyl)-1H-1,4-diazepin-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

Suppliers and Price of Suvorexant intermediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-(4-Benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone 95+%
1g
$ 520.00

Chemenu
(R)-(4-Benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone 95%
1g
$ 486.00

Alichem
(R)-(4-Benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
1g
$ 530.40

Total 7 raw suppliers

Chemical Property of Suvorexant intermediate

Chemical Property:

Boiling Point:583.9±60.0 °C(Predicted)
PKA:7.40±0.40(Predicted)
PSA：54.26000
Density:1.19±0.1 g/cm3(Predicted)
LogP:3.18810
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-(4-Benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Suvorexant intermediate

There total 17 articles about Suvorexant intermediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.36%

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1620097-06-4,1644457-28-2
(R)-1-benzyl-5-methyl-1,4-diazepane

: 1620097-07-5,1644457-29-3
(R)-(4-benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: With benzotriazol-1-ol; triethylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 50 ℃; for 2h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 95.0%

: 1104546-96-4
5-methyl-2-(2Η-1,2,3-triazol-2-yl)benzoyl chloride

: 1-benzyl-5-(R)-methyl-1,4-diazepan dihydrochloride

: 1620097-07-5,1644457-29-3
(R)-(4-benzyl-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: 1-benzyl-5-(R)-methyl-1,4-diazepan dihydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

5-methyl-2-(2Η-1,2,3-triazol-2-yl)benzoyl chloride; In dichloromethane; at 0 - 20 ℃; for 16h;