Suvorexant intermediate

Base Information

Chemical Name:Suvorexant intermediate
CAS No.:1620097-06-4
Molecular Formula:C13H20N2
Molecular Weight:204.31
Hs Code.:
Mol file:1620097-06-4.mol

Synonyms:(R)-1-benzyl-5-methyl-1,4-diazepane;(5R)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine

Suppliers and Price of Suvorexant intermediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-1-Benzyl-5-methyl-1,4-diazepane 97%
5g
$ 265.00

Chemenu
(5R)-1-benzyl-5-methyl-1,4-diazepane 95+%
25g
$ 660.00

Chemenu
(5R)-1-benzyl-5-methyl-1,4-diazepane 95+%
5g
$ 216.00

Chemenu
(5R)-1-benzyl-5-methyl-1,4-diazepane 95+%
10g
$ 330.00

American Custom Chemicals Corporation
1H-1,4-DIAZEPINE, HEXAHYDRO-5-METHYL-1-(PHENYLMETHYL)-, (5R)- 95.00%
5MG
$ 496.27

Ambeed
(R)-1-Benzyl-5-methyl-1,4-diazepane 97%
5g
$ 126.00

Ambeed
(R)-1-Benzyl-5-methyl-1,4-diazepane 97%
1g
$ 43.00

Alichem
(R)-1-Benzyl-5-methyl-1,4-diazepane
10g
$ 805.80

Alichem
(R)-1-Benzyl-5-methyl-1,4-diazepane
5g
$ 499.20

AK Scientific
(R)-1-Benzyl-5-methyl-1,4-diazepane
10g
$ 456.00

Total 42 raw suppliers

Chemical Property of Suvorexant intermediate

Chemical Property:

Boiling Point:296.1±28.0 °C(Predicted)
PKA:10.65±0.40(Predicted)
PSA：15.27000
Density:0.974±0.06 g/cm3(Predicted)
LogP:2.13710
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-Benzyl-5-methyl-1,4-diazepane 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Suvorexant intermediate

There total 14 articles about Suvorexant intermediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.56%

: (R)-4-benzyl-7-methyl-1,4-diazepane-2,5-dione

: 1620097-06-4,1644457-28-2
(R)-1-benzyl-5-methyl-1,4-diazepane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; for 4h; Temperature; Reagent/catalyst; Cooling with ice;

Reference yield: 91.0%

: 150651-57-3
1-Benzyl-2,3,6,7-tetrahydro-5-methyl-1H-1,4-diazepine

: 1620097-06-4,1644457-28-2
1-Benzyl-2,3,4,5,6,7-hexahydro-5-methyl-1H-1,4-diazepine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 4h; Ambient temperature;
DOI:10.1039/P19930001061

Reference yield: 76.0%

: 4-((2-aminoethyl)(benzyl)amino)butan-2-one

: 1620097-06-4,1644457-28-2
(R)-1-benzyl-5-methyl-1,4-diazepane

Guidance literature:: With D-Glucose; glutamate dehydrogenase; NAD; Leishmania major (R)-selective imine reductase Y₁₉₄F/D₂₃₂H mutant; In aq. phosphate buffer; at 30 ℃; for 10h; enantioselective reaction; Kinetics; Enzymatic reaction;
DOI:10.1021/acscatal.0c02400