2-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid
• CAS No.: 92016-94-9
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID10499204,DTXSID80901405
• Mol file: 92016-94-9.mol

Synonyms:92016-94-9;2-(4-methoxyphenyl)cyclopropanecarboxylic acid;2-(4-methoxyphenyl)cyclopropane-1-carboxylic acid;2-(4-Methoxy-phenyl)-cyclopropanecarboxylic acid;MFCD09834141;(1R,2R)-2-(4-methoxyphenyl)cyclopropanecarboxylic acid;5087-21-8;CYCLOPROPANECARBOXYLIC ACID, 2-(4-METHOXYPHENYL)-, (1R,2R)-REL-;MFCD12546170;NoName_517;SCHEMBL432751;(1S,2S)-2-(4-Methoxyphenyl)cyclopropanecarboxylic Acid;DTXSID10499204;DTXSID80901405;CCTYOCDEILYYEF-UHFFFAOYSA-N;MFCD20760251;AKOS005217125;SB46791;AM807355;AS-68216;SY123631;SY205561;SY266133;2-(4-methoxyphenyl)cyclopropanecarboxylicacid;CS-0054285;FT-0695754;FT-0759107;EN300-64472;F51907;A916329;Cyclopropanecarboxylic acid, 2-(4-methoxyphenyl)-

Chemical Property of 2-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid

Chemical Property:

• PSA: 46.53000
• LogP: 1.88330
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 219

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Methoxyphenyl)cyclopropanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2CC2C(=O)O

Technology Process of 2-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid

There total 7 articles about 2-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl trans-2-(4-methoxyphenyl)cyclopropanecarboxylate (948551-64-2) → trans-2-(4-methoxyphenyl)cyclopropanecarboxylic acid (92016-94-9)

Guidance literature:

With water; potassium carbonate; In methanol; at 70 ℃; for 3h;

DOI:10.1016/j.bmc.2010.02.041

Reference yield: 94.2%

2-(4-methoxyphenyl)cyclopropanecarboxylic acid ethyl ester (98017-60-8) → trans-2-(4-methoxyphenyl)cyclopropanecarboxylic acid (92016-94-9)

Guidance literature:

2-(4-methoxyphenyl)cyclopropanecarboxylic acid ethyl ester; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 0 - 20 ℃; for 8h;

With hydrogenchloride; In water;

Reference yield: 73.0%

→ trans-2-(4-methoxyphenyl)cyclopropanecarboxylic acid (92016-94-9)

Guidance literature:

With methanol; sodium hydroxide;

upstream raw materials:

trans-2-(4-methoxyphenyl)cyclopropane-1-carbonitrile

methyl trans-2-(4-methoxyphenyl)cyclopropanecarboxylate

2-(4-methoxyphenyl)cyclopropanecarboxylic acid ethyl ester

4-methoxy-benzaldehyde

Downstream raw materials:

N'-isonicotinoyl-2-(4-methoxyphenyl)cyclopropanecarboxylhydrazide

2-(4-methoxyphenyl)-N'-(phthalazin-1-yl)cyclopropanecarbohydrazide

3-[2-(4-methoxyphenyl)cyclopropyl]-[1,2,4]triazolo[3,4-a]phthalazine

(1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid