(1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid

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Chemical Name:(1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid
CAS No.:1356599-19-3
Molecular Formula:C₂₇H₂₄N₂O₅
Molecular Weight:456.498
Hs Code.:

Synonyms:(1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid

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Chemical Property of (1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid

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Technology Process of (1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid

There total 11 articles about (1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl (1R,2S)-2-{4-[(4-{[(2E,2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylate

: 1356599-19-3
(1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1356599-19-3
(1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; acetic acid / 6 h / 75 °C

1.2: pH 8

2.1: potassium carbonate / acetonitrile / 6 h / 75 °C

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 8 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

With tributylphosphine; hydrogen; sodium acetate; potassium carbonate; acetic acid; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In ethyl acetate; toluene; acetonitrile;

Reference yield:

: 98017-60-8
2-(4-methoxyphenyl)cyclopropanecarboxylic acid ethyl ester

: 1356599-19-3
(1R,2S)-2-{4-[(4-{[(2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 8 h / 0 - 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 8 h / 0 - 20 °C

3.1: boron tribromide / dichloromethane / 0.75 h / 0 - 20 °C

3.2: 20 °C

4.1: sulfuric acid / 1,4-dioxane / 7 h / 100 °C

5.1: potassium hydrogencarbonate / acetone / 0.17 h / 0 °C

5.2: 2 h / 0 - 40 °C

6.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 8 h / 0 - 20 °C

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

With tributylphosphine; sulfuric acid; water; hydrogen; boron tribromide; benzotriazol-1-ol; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; acetone; toluene;