(S,R,R,S)-Nebivolol

Base Information Edit

Chemical Name:(S,R,R,S)-Nebivolol
CAS No.:119365-23-0
Molecular Formula:C₂₂H₂₅F₂NO₄
Molecular Weight:405.442
Hs Code.:
Mol file:119365-23-0.mol

Synonyms:(S,R,R,S)-Nebivolol;[2S-[2R*[S*[S*(R*)]]]]-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-Methanol;R 65260

Suppliers and Price of (S,R,R,S)-Nebivolol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S,R,R,S)-Nebivolol
1mg
$ 185.00

Medical Isotopes, Inc.
(S,R,R,S)-Nebivolol
5 mg
$ 1045.00

Total 1 raw suppliers

Chemical Property of (S,R,R,S)-Nebivolol Edit

Chemical Property:

PSA：70.95000
LogP:2.75450
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(S,R,R,S)-Nebivolol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses The S,R,R,S-enantiomer of Nebivolol (N387900), a metabolite in vitro which acts as a β-adrenergic blocker.

Technology Process of (S,R,R,S)-Nebivolol

There total 64 articles about (S,R,R,S)-Nebivolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1224567-85-4
l-(R,S,S,S)-benzyl nebivolol hydrochloride

: 118457-16-2,118457-14-0,118457-15-1,119365-25-2,119365-23-0,1360598-84-0
nebivolol

Guidance literature:: l-(R,S,S,S)-benzyl nebivolol hydrochloride; With sodium hydroxide; In water; iso-butanol; at 25 ℃; Inert atmosphere;

With formic acid; 5% Pd(II)/C(eggshell); In iso-butanol; at 70 ℃; for 4h;

With sodium hydroxide; In water; iso-butanol;

Reference yield: 62.0%

: 682359-63-3
N-[(S,S)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(R,S)-1-hydroxy-2-(6-fiuoro-chroman-4-one-2-yl)]-amine

: 118457-16-2,118457-14-0,118457-15-1,119365-25-2,119365-23-0,1360598-84-0
nebivolol

Guidance literature:: N-[(S,S)-1-hydroxy-2-(6-fluoro-chroman-4-one-2-yl)]-N-[(R,S)-1-hydroxy-2-(6-fiuoro-chroman-4-one-2-yl)]-amine; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; at 50 - 55 ℃; for 16h; under 2250.23 Torr;

With sodium hydrogencarbonate; In water; pH=8;