7-(6-aMino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:7-(6-aMino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS No.:308353-09-5
Molecular Formula:C₂₀H₁₅F₃N₄O₃
Molecular Weight:416.359
Hs Code.:
Mol file:308353-09-5.mol

Synonyms:7-(6-aMino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Suppliers and Price of 7-(6-aMino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 7-(6-aMino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Chemical Property:

PSA：101.45000
LogP:2.65980

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-(6-aMino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

There total 6 articles about 7-(6-aMino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 146836-84-2
trovafloxacin mesylate

: 308353-09-5
trovafloxacin

Guidance literature:: With water; at 50 ℃; pH=8.5;
DOI:10.1039/a910340f

Reference yield: 75.0%

: 100492-04-4
7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

: 256369-34-3
(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane ditosylate salt

: 308353-09-5
trovafloxacin

: (1α,5α,6α)-7-(-{[6-Carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-difydro-5-oxo-1,8-naphthyridin-2-yl]amino}-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With triethylamine; In methanol; for 16h; Heating;
DOI:10.1039/a910340f

Reference yield:

: 100491-29-0
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

: 308353-09-5
trovafloxacin

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / aq. methanesulfonic acid / 1 h / Heating

2: 75 percent / Et₃N / methanol / 16 h / Heating

With methanesulfonic acid; triethylamine; In methanol; 1: Hydrolysis / 2: Substitution;
DOI:10.1039/a910340f