NAPROXEN METHYL ESTER

Base Information

• Chemical Name: NAPROXEN METHYL ESTER
• CAS No.: 30012-51-2
• Molecular Formula: C15H16O3
• Molecular Weight: 244.29
• Hs Code.: 2918990090
• Mol file: 30012-51-2.mol

Synonyms:2-(6-Methoxynaphthalene-2-yl)propanoic acid methyl ester;6-Methoxy-α-methylnaphthalene-2-acetic acid methyl ester;α-Methyl-6-methoxy-2-naphthaleneacetic acid methyl ester;Methyl 2-(6-methoxynaphthalen-2-yl)propanoate

Chemical Property of NAPROXEN METHYL ESTER

Chemical Property:

• PSA: 35.53000
• LogP: 3.12490

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-(6-methoxynaphthalen-2-yl)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NAPROXEN METHYL ESTER

There total 4 articles about NAPROXEN METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 6-methoxy-2-naphthylacetate (23981-48-8) + carbonic acid dimethyl ester (616-38-6) → methyl 2-methyl-2-phenylpropionate (57625-74-8) + methyl 2-(6-methoxy-2-naphthyl)propionate (30012-51-2)

Guidance literature:

With potassium carbonate; at 220 ℃; for 6h;

Reference yield: 9.0%

1-(6'-methoxy-2'-naphthyl)-2-chloro-1-propanone (76145-94-3) → 6-methoxy-2-propionylnaphthalene (2700-47-2) + methyl 2-(6-methoxy-2-naphthyl)propionate (30012-51-2) + 2-Methoxy-1-(6-methoxy-naphthalen-2-yl)-propan-1-one (76145-97-6)

Guidance literature:

With methyloxirane; In methanol; Irradiation; pH neutral;

DOI:10.1016/S0040-4020(01)80835-8

Reference yield:

naproxen (23981-80-8) → 6-methoxy-2-acetylnaphthalene (3900-45-6) + methyl 2-(6-methoxy-2-naphthyl)propionate (30012-51-2) + 1-(6-methoxy-2-naphthyl)ethanol (108781-65-3,119341-64-9,125712-80-3,77301-42-9) + 2-methoxy-6-(1-methoxyethyl)naphthalene (132367-16-9) + 1,1'-bis(6-methoxy-2-naphtyl)ethoxyethane

Guidance literature:

With ammonium cerium(IV) nitrate; In methanol; for 0.5h; Product distribution; var. molar ratio of the oxidant; other oxidant; also anodic oxidation; sodium salt of naproxen;

DOI:10.1002/jps.2600810519

upstream raw materials:

naproxen

methyl 6-methoxy-2-naphthylacetate

carbonic acid dimethyl ester

1-(6'-methoxy-2'-naphthyl)-2-chloro-1-propanone

Downstream raw materials:

methyl 2-hydroxy-2-(6-methoxynaphth-2-yl)propionate

N’-(4-diethylamino-2-hydroxybenzylidene)-2-(6-methoxynaphthyl)propane hydrazide

N’-(2-hydroxybenzylidene)-2-(6-methoxynaphthyl)propane hydrazide

Refernces

• 1、 Sonawane, Harikisan,Bellur, Nanjundiah S.,Kulkarni, Dilip G.,Ayyangar, Nagaraj R.. "Photochemical Rearrangement of α-Chloro-Propiophenones to α-Arylpropanoic Acids: Studies on Chirality Transfer and Synthesis of (S)-(+)-Ibuprofen and (S)-(+)-Ketoprofen". . p. 1243 - 1260. Retrieved 2007/10/02.
• 2、 -. "Manufacture of alpha-arylalkanoic acids and precursors". . . Retrieved 2008/06/13.