1,4,7,10-Tetraoxacyclododecino[2,3-g]quinolin-15(12H)-one, 2,3,5,6,8,9-hexahydro-

Base Information

• Chemical Name: 1,4,7,10-Tetraoxacyclododecino[2,3-g]quinolin-15(12H)-one, 2,3,5,6,8,9-hexahydro-
• CAS No.: 1355620-88-0
• Molecular Formula: C15H17NO5
• Molecular Weight: 291.304
• Mol file: 1355620-88-0.mol

Synonyms:1,4,7,10-Tetraoxacyclododecino[2,3-g]quinolin-15(12H)-one, 2,3,5,6,8,9-hexahydro-;1,4,7,10-Tetraoxacyclodod...;2,3,5,6,8,9-Hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinolin-15(12H)-one

Chemical Property of 1,4,7,10-Tetraoxacyclododecino[2,3-g]quinolin-15(12H)-one, 2,3,5,6,8,9-hexahydro-

Chemical Property:

• PSA: 69.78000
• LogP: 1.33250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2,3,5,6,8,9-Hexahydro-1,4,7,10-tetraoxacyclododecino[2,3-G]quinolin-15(12H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,7,10-Tetraoxacyclododecino[2,3-g]quinolin-15(12H)-one, 2,3,5,6,8,9-hexahydro-

There total 3 articles about 1,4,7,10-Tetraoxacyclododecino[2,3-g]quinolin-15(12H)-one, 2,3,5,6,8,9-hexahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(3-amino-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone (1355620-87-9) + formic acid ethyl ester (109-94-4) → 7,8,10,11,13,14-hexahydro-1H-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-one (1355620-88-0)

Guidance literature:

1-(3-amino-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone; With sodium methylate; In 1,2-dimethoxyethane; for 0.5h;

formic acid ethyl ester; In 1,2-dimethoxyethane;

Reference yield:

1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone (107996-83-8) → 7,8,10,11,13,14-hexahydro-1H-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-one (1355620-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; sulfuric acid / dichloromethane / 1.33 h / 0 °C

2: ammonium acetate; iron / toluene; water / Reflux

3: sodium methylate / 1,2-dimethoxyethane / 0.5 h

With sulfuric acid; ammonium acetate; nitric acid; sodium methylate; iron; In 1,2-dimethoxyethane; dichloromethane; water; toluene;

Reference yield:

1-(3-nitro-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone (1355620-86-8) → 7,8,10,11,13,14-hexahydro-1H-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-one (1355620-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate; iron / toluene; water / Reflux

2: sodium methylate / 1,2-dimethoxyethane / 0.5 h

With ammonium acetate; sodium methylate; iron; In 1,2-dimethoxyethane; water; toluene;

upstream raw materials:

1-(3-amino-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone

formic acid ethyl ester

1-(6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone

1-(3-nitro-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone

Downstream raw materials:

4-(2-fluoro-4-nitro-phenoxy)-7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalene

4-(4-amino-2-fluoro-phenoxy)-7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalene

5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

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