5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

Base Information

Chemical Name:5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide
CAS No.:1355620-37-9
Molecular Formula:C₃₃H₂₇F₂N₃O₇
Molecular Weight:615.59
Hs Code.:

5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

Synonyms:5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

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Chemical Property of 5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

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Technology Process of 5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

There total 5 articles about 5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1052114-81-4
5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridin-3-ylcarboxylic acid

: 1355620-90-4
4-(4-amino-2-fluoro-phenoxy)-7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalene

: 1355620-37-9
5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;

Reference yield:

: 1355620-87-9
1-(3-amino-6,7,9,10,12,13-hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone

: 1355620-37-9
5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / 1,2-dimethoxyethane / 0.5 h

2: caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 2.5 h / 20 °C

3: triethylamine; hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; methanol / 1810.07 Torr

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With hydrogen; sodium methylate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1355620-88-0
7,8,10,11,13,14-hexahydro-1H-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-one

: 1355620-37-9
5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 2.5 h / 20 °C

2: triethylamine; hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; methanol / 1810.07 Torr

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;