3-(Pyridin-2-yl)prop-2-enamide

Base Information

Chemical Name:3-(Pyridin-2-yl)prop-2-enamide
CAS No.:99584-02-8
Molecular Formula:C₈H₈N₂O
Molecular Weight:148.164
Hs Code.:2933399090
DSSTox Substance ID:DTXSID00698906
Mol file:99584-02-8.mol

Synonyms:3-(Pyridin-2-yl)prop-2-enamide;SCHEMBL1382336;DTXSID00698906

Suppliers and Price of 3-(Pyridin-2-yl)prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-(Pyridin-2-yl)prop-2-enamide

Chemical Property:

PSA：56.97000
LogP:1.72980
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:148.063662883
Heavy Atom Count:11
Complexity:166

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)C=CC(=O)N

Technology Process of 3-(Pyridin-2-yl)prop-2-enamide

There total 8 articles about 3-(Pyridin-2-yl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3-(pyridin-2-yl)propiolamide

: 99584-02-8,155375-22-7,155375-23-8
(E)-3-(pyridin-2-yl)acrylamide

Guidance literature:: With potassium tert-butylate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 20 ℃; for 0.166667h; stereoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.0c02567

Reference yield: 56.0%

: 110-86-1
pyridine

: 79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5
2-propenamide

: 99584-02-8,155375-22-7,155375-23-8
(E)-3-(pyridin-2-yl)acrylamide

Guidance literature:: With oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 140 ℃; for 20h; under 760.051 Torr; regioselective reaction;
DOI:10.1002/adsc.201200195

Reference yield:

: 54495-51-1
(E)-3-(2-pyridyl)acrylic acid

: 99584-02-8,155375-22-7,155375-23-8
(E)-3-(pyridin-2-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; concentrated H₂SO₄

2: aq.-ethanolic NH₃

With ethanol; sulfuric acid; ammonia;