2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)

Base Information

• Chemical Name: 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)
• CAS No.: 155375-22-7
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Mol file: 155375-22-7.mol

Synonyms:2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)

Chemical Property of 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)

Chemical Property:

• Boiling Point: 376.6±34.0 °C(Predicted)
• PKA: 14.49±0.50(Predicted)
• PSA: 55.98000
• Density: 1.190±0.06 g/cm3(Predicted)
• LogP: 1.28040

Purity/Quality:

(2E)-3-(PYRIDIN-2-YL)PROP-2-ENAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI)

There total 9 articles about 2-Propenamide,3-(2-pyridinyl)-,(E)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(pyridin-2-yl)propiolamide → (E)-3-(pyridin-2-yl)acrylamide (99584-02-8,155375-22-7,155375-23-8)

Guidance literature:

With potassium tert-butylate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 20 ℃; for 0.166667h; stereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c02567

Reference yield: 56.0%

pyridine (110-86-1) + 2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) → (E)-3-(pyridin-2-yl)acrylamide (99584-02-8,155375-22-7,155375-23-8)

Guidance literature:

With oxygen; silver(I) acetate; palladium diacetate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 140 ℃; for 20h; under 760.051 Torr; regioselective reaction;

DOI:10.1002/adsc.201200195

Reference yield:

(E)-3-(2-pyridyl)acrylic acid (54495-51-1) → (E)-3-(pyridin-2-yl)acrylamide (99584-02-8,155375-22-7,155375-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; concentrated H₂SO₄

2: aq.-ethanolic NH₃

With ethanol; sulfuric acid; ammonia;

upstream raw materials:

(E)-ethyl 3-(2-pyridyl)-propenoate

(E)-3-(2-pyridyl)acrylic acid

pyridine

2-propenamide

Downstream raw materials:

(Z)-3-(2-Pyridyl)propenamide

3-(2-pyridyl)-prop-2-enyl nitrile