5H-Indazol-5-one, 2,4,6,7-tetrahydro-2-methyl-

Base Information

• Chemical Name: 5H-Indazol-5-one, 2,4,6,7-tetrahydro-2-methyl-
• CAS No.: 904664-22-8
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Mol file: 904664-22-8.mol

Synonyms:5H-Indazol-5-one, 2,4,6,7-tetrahydro-2-methyl-;2-methyl-6,7-dihydro-2H-indazol-5(4H)-one

Chemical Property of 5H-Indazol-5-one, 2,4,6,7-tetrahydro-2-methyl-

Chemical Property:

• PSA: 34.89000
• LogP: 0.47790

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-Indazol-5-one, 2,4,6,7-tetrahydro-2-methyl-

There total 2 articles about 5H-Indazol-5-one, 2,4,6,7-tetrahydro-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

7-(hydroxymethylene)-1,4-dioxaspiro<4.5>decan-8-one (115215-91-3) + methylhydrazine (60-34-4) → 2-methyl-2,4,6,7-tetrahydro-5H-indazol-5-one (904664-22-8) + 1,4,6,7-tetrahydro-1-methyl-5H-indazol-5-one (115215-92-4)

Guidance literature:

7-(hydroxymethylene)-1,4-dioxaspiro<4.5>decan-8-one; methylhydrazine; In methanol; at -30 - 20 ℃;

With hydrogenchloride; In water; acetone; at 60 ℃; for 2h;

DOI:10.1002/jhet.5570430328

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 2-methyl-2,4,6,7-tetrahydro-5H-indazol-5-one (904664-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 90 percent / NaH / ethanol; tetrahydrofuran / 2 h / Heating

2.1: methanol / -30 - 20 °C

2.2: 36 percent / HCl / acetone; H₂O / 2 h / 60 °C

With sodium hydride; In tetrahydrofuran; methanol; ethanol;

DOI:10.1002/jhet.5570430328

Reference yield: 88.0%

2-methyl-2,4,6,7-tetrahydro-5H-indazol-5-one (904664-22-8) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-methyl-N'-(2-methyl-2,4,6,7-tetrahydro-5H-indazol-5-ylidene)benzenesulfonohydrazide

Guidance literature:

In methanol; at 20 ℃; for 1h;

DOI:10.1002/jhet.5570430328

upstream raw materials:

7-(hydroxymethylene)-1,4-dioxaspiro<4.5>decan-8-one

methylhydrazine

cyclohexanedione monoethylene ketal