tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate

Base Information

• Chemical Name: tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate
• CAS No.: 1419221-63-8
• Molecular Formula: C11H14F2N2O2
• Molecular Weight: 244.2378664
• Hs Code.: 2933399990
• Mol file: 1419221-63-8.mol

Synonyms:tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate

Chemical Property of tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate

Chemical Property:

• PSA: 51.22000
• LogP: 3.43920

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl (4-(difluoromethyl)-pyridin-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate

There total 3 articles about tert-butyl (4-(difluoroMethyl)pyridin-2-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl carbazate (4248-19-5) + 2-chloro-4-(difluoromethyl)pyridine (1204296-03-6) → tert-butyl (4-(difluoromethyl)pyridin-2-yl)carbamate (1419221-63-8)

Guidance literature:

With palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane;

DOI:10.1021/acs.oprd.9b00312

Reference yield:

2-chloro-4-iodopyridine (153034-86-7) → tert-butyl (4-(difluoromethyl)pyridin-2-yl)carbamate (1419221-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate; copper(l) chloride

2: palladium diacetate; caesium carbonate; XPhos / 1,4-dioxane

With potassium tert-butylate; palladium diacetate; caesium carbonate; copper(l) chloride; XPhos; In 1,4-dioxane; 2: |Buchwald-Hartwig Coupling;

DOI:10.1021/acs.oprd.9b00312

Reference yield:

2-chloropyridine-4-carbaldehyde (101066-61-9) → tert-butyl (4-(difluoromethyl)pyridin-2-yl)carbamate (1419221-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane

2: palladium diacetate; caesium carbonate; XPhos / 1,4-dioxane

With diethylamino-sulfur trifluoride; palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane; dichloromethane; 2: |Buchwald-Hartwig Coupling;

DOI:10.1021/acs.oprd.9b00312

upstream raw materials:

tert-butyl carbazate

2-chloro-4-(difluoromethyl)pyridine

2-chloro-4-iodopyridine

2-chloropyridine-4-carbaldehyde

Downstream raw materials:

4-bromo-N-(4-(difluoromethyl)pyridin-2-yl)-3-fluorobenzamide

N-(4-(difluoromethyl)pyridin-2-yl)-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

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