1204296-03-6

Basic information

• Product Name: 2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE
• Synonyms: 2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE
• CAS NO: 1204296-03-6
• Molecular Formula: C₆H₄ClF₂N
• Molecular Weight: 164
• Mol File: 1204296-03-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 203℃
• Flash Point: 76℃
• Appearance: /
• Density: 1.334
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.56±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE(1204296-03-6)
• EPA Substance Registry System: 2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE(1204296-03-6)

Safety Data

• Hazardous Substances Data: 1204296-03-6(Hazardous Substances Data)

Usage

Description

2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE is a pyridine derivative with the molecular formula C6H3ClF2N, featuring a chlorine atom at the 2-position and a difluoromethyl group at the 4-position. This chemical compound serves as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds, as well as a building block for the production of various heterocyclic compounds. It holds potential in the field of medicinal chemistry and drug discovery, although it requires careful handling due to its potential harmful effects if ingested, inhaled, or causing skin and eye irritation.

Uses

Used in Pharmaceutical Industry:
2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE is utilized as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Organic Synthesis:
2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE is employed as a building block in organic synthesis, enabling the construction of a wide range of heterocyclic compounds with diverse applications in various industries.
Used in Medicinal Chemistry and Drug Discovery:
2-CHLORO-4-(DIFLUOROMETHYL)PYRIDINE is used as a key component in medicinal chemistry and drug discovery processes, potentially leading to the identification and development of novel therapeutic agents with improved efficacy and safety profiles.

Upstream product

• 153034-86-7 2-chloro-4-iodopyridine 
• 65864-64-4 trimethyl(difluoromethyl)silane 
• 101066-61-9 2-chloropyridine-4-carbaldehyde 

Downstream Products

• 109919-29-1 2-chloro-4-[chloro(difluoro)methyl]pyridine 
• 1927857-56-4 PQR620 
• 1927857-61-1 4-(difluoromethyl)-5-{4-[(3R)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine 
• 1620677-32-8 4-bromo-N-(4-(difluoromethyl)pyridin-2-yl)-3-fluorobenzamide 
• 1419221-62-7 N-(4-(difluoromethyl)pyridin-2-yl)-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 1419221-63-8 tert-butyl (4-(difluoromethyl)pyridin-2-yl)carbamate 
• 1609978-81-5 14,14-dimethyl-3,12-dioxo-2,4,13-trioxa-11-azapentadec-1-yl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1609977-15-2 ({[(6-aminohexyl)oxy]carbonyl}oxy)methyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate trifluoroacetate 
• 1609976-88-6 phenyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1609978-79-1 trans-3-{[(benzyloxy)carbonyl]amino}cyclobutyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1609976-87-5 trans-3-aminocyclobutyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1609978-78-0 benzyl 2,3,4-tri-O-benzyl-6-O-({trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexyl}carbonyl)-D-glucopyranoside 
• 1609976-99-9 [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 
• 1609976-85-3 (2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate 

Relevant articles and documents

Scalable, Economical, and Practical Synthesis of 4-(Difluoromethyl)pyridin-2-amine, a Key Intermediate for Lipid Kinase Inhibitors

A new, scalable, rapid, high yielding, and practical synthesis of 4-(difluoromethyl)pyridin-2-amine provides a key intermediate for the preparation of numerous protein kinase inhibitors and clinical candidates targeting phosphoinositide 3-kinase (PI3K) and the mechanistic target of rapamycin (mTOR) kinase. Starting from 2,2-difluoroacetic anhydride, an efficient five-step and two-pot procedure to prepare 4-(difluoromethyl)pyridin-2-amine (1) has been developed. Noteworthy aspects of this strategy include the avoidance of an amination process using a sealed vessel. Each step of the synthetic route has been optimized, and key intermediates have been isolated and characterized prior to the final two-pot procedure, which has been successfully applied for large-scale production.

PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

PYRAZOLYL PYRROLINONES AND THEIR USE AS HERBICIDES

The invention relates to pyrrolone compounds of the formula (I) wherein X, R1, R2, R3 and A are as defined in the specification. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (I), to herbicidal compositions comprising these compounds and to methods of using these compounds to control plant growth.