4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine

Base Information

• Chemical Name: 4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine
• CAS No.: 1246349-97-2
• Molecular Formula: C14H11ClIN3O
• Molecular Weight: 399.618
• Hs Code.: 2933990090
• Mol file: 1246349-97-2.mol

Synonyms:4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine;4-Chloro-3-iodo-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[4,3-c]pyridine;1-(4-methoxybenzyl)-4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine

Chemical Property of 4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine

Chemical Property:

• Boiling Point: 526.5±50.0 °C(Predicted)
• PKA: 3.54±0.30(Predicted)
• PSA: 39.94000
• Density: 1.77
• LogP: 3.74620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine

There total 8 articles about 4-Chloro-3-iodo-1-(4-Methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine (1186647-69-7) + p-methoxybenzyl chloride (824-94-2) → 4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine (1246349-97-2)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine (1186647-69-7) + p-methoxybenzyl chloride (824-94-2) → 4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine (1246349-97-2) + C14H11ClIN3O

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

Reference yield:

4-chloro-1H-pyrazolo [4,3-c]pyridine (871836-51-0) → 4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine (1246349-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 75 °C

2: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

With iodine; potassium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine

p-methoxybenzyl chloride

2,4-dichloro-3-pyridine Carboxaldehyde

2,4-dichloropyridine

Downstream raw materials:

cyclohexyl-[3-iodo-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-4-yl]-amine

(E)-3-[4-chloro-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-acrylic acid methyl ester

4-cyclohexyloxy-3-iodo-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridine

4-[2-(4-cyclohexylamino-1H-pyrazolo[4,3-c]pyridin-3-yl)-ethyl]-benzoic acid methyl ester

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