2,4-Dichloronicotinaldehyde

Base Information

• Chemical Name: 2,4-Dichloronicotinaldehyde
• CAS No.: 134031-24-6
• Molecular Formula: C6H3Cl2NO
• Molecular Weight: 176.002
• Hs Code.: 2933399090
• European Community (EC) Number: 686-961-2
• DSSTox Substance ID: DTXSID00567608
• Nikkaji Number: J403.435J
• Wikidata: Q72467961
• Mol file: 134031-24-6.mol

Synonyms:2,4-dichloronicotinaldehyde;134031-24-6;2,4-Dichloropyridine-3-carboxaldehyde;2,4-dichloropyridine-3-carbaldehyde;2,4-dichloro-3-pyridinecarboxaldehyde;MFCD07437909;3-Pyridinecarboxaldehyde, 2,4-dichloro-;SCHEMBL304349;2,4-dichloro-3-formylpyridine;DTXSID00567608;GWBHJHIZHNTJLA-UHFFFAOYSA-N;BCP18677;2,4-dichloro-3-pyridinecarbaldehyde;2,4-dichloro-pyridine-3-carbaldehyde;2.4-Dichloro-pyridine-3-carbaldehyde;AKOS005071911;AB41952;BC-0813;CS-W019767;2,4-dichloro-3-pyridine carboxaldehyde;AC-23716;SY020935;2,4-Dichloropyridine-3-carboxaldehyde, 97%;AM20061766;D5076;EN300-100867;A806719;J-507180

Chemical Property of 2,4-Dichloronicotinaldehyde

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Melting Point: 72-75℃
• Refractive Index: 1.608
• Boiling Point: 261.753 °C at 760 mmHg
• PKA: -1.17±0.10(Predicted)
• Flash Point: 112.104 °C
• PSA: 29.96000
• Density: 1.489 g/cm³
• LogP: 2.20090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.9591691
• Heavy Atom Count: 10
• Complexity: 131

Purity/Quality:

≥99% ^*data from raw suppliers

2,4-Dichloronicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=C1Cl)C=O)Cl

Technology Process of 2,4-Dichloronicotinaldehyde

There total 5 articles about 2,4-Dichloronicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,4-dichloropyridine (26452-80-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-dichloro-3-pyridine Carboxaldehyde (134031-24-6)

Guidance literature:

2,4-dichloropyridine; With lithium diisopropyl amide;

N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2010.11.108

Reference yield: 67.0%

Methyl formate (107-31-3) → 2,4-dichloro-3-pyridine Carboxaldehyde (134031-24-6)

Guidance literature:

2,4-dichloropyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 1.5h;

Methyl formate; In tetrahydrofuran; for 0.5h;

Reference yield: 54.0%

N-Formylpiperidine (2591-86-8) + 2,4-dichloropyridine (26452-80-2) → 2,4-dichloro-3-pyridine Carboxaldehyde (134031-24-6)

Guidance literature:

2,4-dichloropyridine; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 3.5h;

N-Formylpiperidine; In tetrahydrofuran; at -78 ℃; for 1.5h;

upstream raw materials:

N-Formylpiperidine

2,4-dichloropyridine

Methyl formate

N,N-dimethyl-formamide

Downstream raw materials:

(2,4-dichloropyridin-3-yl)methanol

1-(2,4-dichloropyridin-3-yl)ethan-1-ol

4-chloro-1H-pyrazolo [4,3-c]pyridine

4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine