AZD 3759

Base Information

Chemical Name:AZD 3759
CAS No.:1626387-80-1
Molecular Formula:C₂₂H₂₃ClFN₅O₃
Molecular Weight:459.908
Hs Code.:
Mol file:1626387-80-1.mol

Synonyms:AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-

Suppliers and Price of AZD 3759

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AZD 3759
100mg
$ 1168.00

TRC
AZD3759
25mg
$ 170.00

Medical Isotopes, Inc.
AZD3759
1 g
$ 490.00

DC Chemicals
AZD-3759 >98%
100 mg
$ 250.00

DC Chemicals
AZD-3759 >98%
250 mg
$ 500.00

DC Chemicals
AZD-3759 >98%
1 g
$ 900.00

Crysdot
AZD3759 98+%
100mg
$ 569.00

Crysdot
AZD3759 98+%
50mg
$ 362.00

ChemScene
Zorifertinib 99.76%
50mg
$ 120.00

ChemScene
Zorifertinib 99.76%
10mg
$ 60.00

Total 84 raw suppliers

Chemical Property of AZD 3759

Chemical Property:

Appearance/Colour:white to off-white solid
Melting Point:192.4 °C(alkyl acetate or alcohol), 193.3 °C (water)
Boiling Point:571.4±50.0 °C(Predicted)
PKA:6.71±0.40(Predicted)
PSA：79.82000
Density:1.358±0.06 g/cm3(Predicted)
LogP:4.25800
Solubility.:≥23 mg/mL in DMSO; insoluble in H2O; ≥8.32 mg/mL in EtOH with ultrasonic

Purity/Quality:

>95% ^*data from raw suppliers

AZD 3759 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system.
Uses AZD 3759 is EGFR inhibitor. It is a potent, oral active, central nervous system-penetrant, epidermal growth factor receptor tyrosine kinase inhibitor.

Technology Process of AZD 3759

There total 46 articles about AZD 3759 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.079%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 4-tert-butyl-1-4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl (2R)-2-methylpiperazine-1,4-dicarboxylate

: 1626387-80-1
(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl-2,4-dimethylpiperazinyl-1-carboxylic acid ester

Guidance literature:: With formic acid; In water; at 90 - 100 ℃; for 3h;

Reference yield: 83.6%

: 2106-04-9
3-chloro-2-fluoroaniline

: (R)-4-chloro-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate

: 1626387-80-1
(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl-2,4-dimethylpiperazinyl-1-carboxylic acid ester

Guidance literature:: In isopropyl alcohol; for 3h; Reflux;

Reference yield: 27.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: (±)-4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl-2-methylpiperazine-1-carboxylate

: 1626387-80-1
4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl (±)-2,4-dimethylpiperazine-1-carboxylate

Guidance literature:: formaldehyd; (±)-4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl-2-methylpiperazine-1-carboxylate; With acetic acid; In methanol; at 20 ℃; for 2h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 2h;