6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one

Base Information

• Chemical Name: 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
• CAS No.: 179688-52-9
• Molecular Formula: C9H8N2O3
• Molecular Weight: 192.174
• Hs Code.: 2933990090
• Mol file: 179688-52-9.mol

Synonyms:4(1H)-Quinazolinone,6-hydroxy-7-methoxy- (9CI);6-Hydroxy-7-methoxyquinazolin-4(3H)-one;7-Methoxyquinazoline-4,6-diol;

Chemical Property of 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 293 °C
• Refractive Index: 1.659
• Boiling Point: 503.319 °C at 760 mmHg
• PKA: 9.39±0.20(Predicted)
• Flash Point: 258.198 °C
• PSA: 75.21000
• Density: 1.478 g/cm³
• LogP: 0.63730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Hydroxy-7-methoxy-4(1H)-quinazolinone is a reactant used in the preparation of 4-anilinoquinazoline derivatives that have shown antitumor activities. 6-Hydroxy-7-methoxy-4(1H)-quinazolinone was also used as a reactant in the synthetic preparation of 2-arylbenzothiazoles as kinase inhibitors.

Technology Process of 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one

There total 40 articles about 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3H-6,7-dimethoxyquinazolin-4-one (13794-72-4) → 6-hydroxy-7-methoxyquinazolin-4(3H)-one (179688-52-9)

Guidance literature:

With methanesulfonic acid; DL-methionine; at 120 ℃; for 30h;

DOI:10.1016/j.ejmech.2008.07.023

Reference yield: 98.0%

6-hydroxy-7-methoxyquinazoline (884344-38-1) → 6-hydroxy-7-methoxyquinazolin-4(3H)-one (179688-52-9)

Guidance literature:

With peracetic acid; sulfuric acid; In ethanol; at 60 ℃; for 12h;

DOI:10.1080/00397911.2013.805230

Reference yield: 97.0%

L-Methionone + 3H-6,7-dimethoxyquinazolin-4-one (13794-72-4) → 6-hydroxy-7-methoxyquinazolin-4(3H)-one (179688-52-9)

Guidance literature:

In methanesulfonic acid; water;

upstream raw materials:

3H-6,7-dimethoxyquinazolin-4-one

L-methionine

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

methyl 2-amino-5-hydroxy-4-methoxybenzoate

Downstream raw materials:

6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

6-acetoxy-4-chloro-7-methoxyquinazoline

4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride salt

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline