5-[2,4-Bis(benzyloxy)-5-isopropylphenyl]-N-ethyl-4-(4-forMylphenyl)isoxazole-3-carboxaMide

Base Information

Chemical Name:5-[2,4-Bis(benzyloxy)-5-isopropylphenyl]-N-ethyl-4-(4-forMylphenyl)isoxazole-3-carboxaMide
CAS No.:747414-23-9
Molecular Formula:C36H34N2O5
Molecular Weight:574.676
Hs Code.:
Mol file:747414-23-9.mol

Synonyms:5-[2,4-Bis(benzyloxy)-5-isopropylphenyl]-N-ethyl-4-(4-forMylphenyl)isoxazole-3-carboxaMide

Suppliers and Price of 5-[2,4-Bis(benzyloxy)-5-isopropylphenyl]-N-ethyl-4-(4-forMylphenyl)isoxazole-3-carboxaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 5-[2,4-Bis(benzyloxy)-5-isopropylphenyl]-N-ethyl-4-(4-forMylphenyl)isoxazole-3-carboxaMide

Chemical Property:

PSA：90.66000
LogP:8.24310

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-[2,4-Bis(benzyloxy)-5-isopropylphenyl]-N-ethyl-4-(4-forMylphenyl)isoxazole-3-carboxaMide

There total 1 articles about 5-[2,4-Bis(benzyloxy)-5-isopropylphenyl]-N-ethyl-4-(4-forMylphenyl)isoxazole-3-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 747414-22-8
5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylic acid ethylamide

: 87199-17-5
4-formylphenylboronic acid,

: 747414-23-9
5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 75.0%

: 747414-23-9
5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylic acid ethylamide

: 51857-17-1
tert-butyl N-(6-aminohexyl)carbamate

: 1301630-39-6
tert-butyl 6-(4-(5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-3-(ethylcarbamoyl)isoxazol-4-yl)benzylamino)hexylcarbamate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 1h; Molecular sieve;
DOI:10.1016/j.bmc.2011.03.013

Reference yield: 29.0%

: 747414-23-9
5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylic acid ethylamide

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1133784-24-3
Methyl 3-(4-(5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-3-(ethylcarbamoyl)-isoxazol-4-yl)benzylamino)propanoate

Guidance literature:: 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-(4-formylphenyl)isoxazole-3-carboxylic acid ethylamide; methyl 3-aminopropanoate hydrochloride; With magnesium sulfate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 3h;

With sodium cyanoborohydride; In dichloromethane;