5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol

Base Information

• Chemical Name: 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol
• CAS No.: 1192140-15-0
• Molecular Formula: C14H12N2O
• Molecular Weight: 224.25788
• Mol file: 1192140-15-0.mol

Synonyms:5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol;5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3(2H)-one

Chemical Property of 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol

Chemical Property:

• PKA: 8.16±0.70(Predicted)
• PSA: 37.79000
• Density: 1.232±0.06 g/cm3(Predicted)
• LogP: 2.62720

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol

There total 6 articles about 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(2,4-dimethyl-1,3-dioxolan-2-yl)acetic acid (1356907-02-2) + 2-naphthylhydrazine hydrochloride (2243-58-5) → 5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol (1192140-15-0)

Guidance literature:

2-(2,4-dimethyl-1,3-dioxolan-2-yl)acetic acid; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

2-naphthylhydrazine hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 3h; Product distribution / selectivity;

Reference yield: 91.0%

2-(2,4-dimethyl-1,3-dioxolan-2-yl)-N'-(naphthalen-2-yl)acetohydrazide (1356907-03-3) → 5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol (1192140-15-0)

Guidance literature:

2-(2,4-dimethyl-1,3-dioxolan-2-yl)-N'-(naphthalen-2-yl)acetohydrazide; With hydrogenchloride; water; In methanol; for 1h; Reflux;

With sodium hydroxide; In methanol; water; pH=~ 14; Product distribution / selectivity;

Reference yield: 65.0%

2,5-dimethyl-2-(naphthalen-2-yldiazenyl)furan-3(2H)-one (1192140-19-4) → 5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3(2H)-one (1192140-15-0)

Guidance literature:

2,5-dimethyl-2-(naphthalen-2-yldiazenyl)furan-3(2H)-one; With hydrogenchloride; acetic acid; In water; at 65 ℃; for 2h;

With sodium hydroxide; In water; pH=10 - 12;

upstream raw materials:

2,5-dimethyl-2-(naphthalen-2-yldiazenyl)furan-3(2H)-one

ethyl 2-(2,4-dimethyl-1,3-dioxolan-2-yl)acetate

2-naphthylhydrazine hydrochloride

2-(2,4-dimethyl-1,3-dioxolan-2-yl)-N'-(naphthalen-2-yl)acetohydrazide

Downstream raw materials:

4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine