Landiololhydrochloride

Base Information

• Chemical Name: Landiololhydrochloride
• CAS No.: 133242-62-3
• Molecular Formula: C₂₅H₃₉N₃O₈
• Molecular Weight: 509.6
• DSSTox Substance ID: DTXSID40861374
• Mol file: 133242-62-3.mol

Synonyms:Landiololhydrochloride;SCHEMBL121447;DTXSID40861374;FT-0654610;FT-0697568;L001438;(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 3-{4-[2-hydroxy-3-({2-[(morpholine-4-carbonyl)amino]ethyl}amino)propoxy]phenyl}propanoate

Chemical Property of Landiololhydrochloride

Chemical Property:

• PSA: 127.82000
• LogP: 1.40470
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 14
• Exact Mass: 509.27371521
• Heavy Atom Count: 36
• Complexity: 666

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(OCC(O1)COC(=O)CCC2=CC=C(C=C2)OCC(CNCCNC(=O)N3CCOCC3)O)C

Technology Process of Landiololhydrochloride

There total 6 articles about Landiololhydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxyphenylpropionic acid (501-97-3) → (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-[4-[2-hydroxy-3-(2-morpholinocarbonylaminoethyl)aminopropoxy]phenyl]propionate (133242-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / dimethylsulfoxide / 1 h / 100 °C

2: K₂CO₃ / dimethylformamide / 15 h / 70 °C

3: propan-2-ol / 15 h / Ambient temperature

With potassium hydroxide; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1248/cpb.40.1462

Reference yield:

(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-hydroxyphenyl)propionate (133242-63-4) → (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-[4-[2-hydroxy-3-(2-morpholinocarbonylaminoethyl)aminopropoxy]phenyl]propionate (133242-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 15 h / 70 °C

2: propan-2-ol / 15 h / Ambient temperature

With potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1248/cpb.40.1462

Reference yield:

solketal tosylate (23737-51-1,7305-59-1) → (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-[4-[2-hydroxy-3-(2-morpholinocarbonylaminoethyl)aminopropoxy]phenyl]propionate (133242-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / dimethylsulfoxide / 1 h / 100 °C

2: K₂CO₃ / dimethylformamide / 15 h / 70 °C

3: propan-2-ol / 15 h / Ambient temperature

With potassium hydroxide; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1248/cpb.40.1462

upstream raw materials:

N-(2-aminoethyl)-4-morpholine carboxamide

(2,2-dimethyl-1,3-dioxolan4-yl)methyl 3-[4-(2,3-epoxypropoxy)-phenyl]propionate

4-hydroxyphenylpropionic acid

4-[(1H-imidazol-1-yl)carbonyl]morpholine