Ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate

Base Information

Chemical Name:Ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate
CAS No.:874758-54-0
Molecular Formula:C14H15F3O10S
Molecular Weight:432.328
Hs Code.:
DSSTox Substance ID:DTXSID801116323
Mol file:874758-54-0.mol

Synonyms:874758-54-0;Ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate;ethyl 2-hydroxy-2-[6-(methoxymethoxy)-7-(trifluoromethylsulfonyloxy)-1,3-benzodioxol-4-yl]acetate;SCHEMBL1755321;DTXSID801116323;CS-M2926;ZJB75854;AKOS037650458;CS-14841;C12806;Ethyl alpha-hydroxy-6-(methoxymethoxy)-7-[[(trifluoromethyl)sulfonyl]oxy]-1,3-benzodioxole-4-acetate;Ethyl2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate

Suppliers and Price of Ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate

Chemical Property:

PSA：135.20000
LogP:2.30370
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:9
Exact Mass:432.03380233
Heavy Atom Count:28
Complexity:634

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C1=CC(=C(C2=C1OCO2)OS(=O)(=O)C(F)(F)F)OCOC)O

Technology Process of Ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate

There total 4 articles about Ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-(((trifluoromethyl)sulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 874758-53-9
hydroxy-(7-hydroxy-6-methoxymethoxy-benzo[1,3]dioxol-4-yl)-acetic acid ethyl ester

: 17763-80-3
para-nitrophenyl triflate

: 874758-54-0
hydroxy-(6-methoxymethoxy-7-trifluoromethanesulfonyloxy-benzo[1,3]dioxol-4-yl)-acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 1h;
DOI:10.1021/ja0571794

Reference yield:

: 533-31-3
Sesamol

: 874758-54-0
hydroxy-(6-methoxymethoxy-7-trifluoromethanesulfonyloxy-benzo[1,3]dioxol-4-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / NaH / diethyl ether; dimethylformamide / 0 - 20 °C

2.1: n-BuLi; B(OMe)3 / tetrahydrofuran

2.2: 95 percent / AcOH; H₂O₂ / 0 - 20 °C

3.1: 97 percent / LiCl; 3 Angstroem molecular sieves / toluene; various solvent(s) / 24 h / 20 °C

4.1: 95 percent / K₂CO₃ / dimethylformamide / 1 h / 23 °C

With n-butyllithium; Trimethyl borate; 3 A molecular sieve; sodium hydride; potassium carbonate; lithium chloride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene; 3.1: Friedel-Crafts reaction;
DOI:10.1021/ja0571794

Reference yield:

: 111726-43-3
3,4-(methylenedioxy)phenyl methoxymethyl ether

: 874758-54-0
hydroxy-(6-methoxymethoxy-7-trifluoromethanesulfonyloxy-benzo[1,3]dioxol-4-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; B(OMe)3 / tetrahydrofuran

1.2: 95 percent / AcOH; H₂O₂ / 0 - 20 °C

2.1: 97 percent / LiCl; 3 Angstroem molecular sieves / toluene; various solvent(s) / 24 h / 20 °C

3.1: 95 percent / K₂CO₃ / dimethylformamide / 1 h / 23 °C

With n-butyllithium; Trimethyl borate; 3 A molecular sieve; potassium carbonate; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2.1: Friedel-Crafts reaction;
DOI:10.1021/ja0571794