tert-butyl (3-tosyl-cyclobutyl)-carbamate

Base Information

• Chemical Name: tert-butyl (3-tosyl-cyclobutyl)-carbamate
• CAS No.: 878156-25-3
• Molecular Formula: C16H23NO5S
• Molecular Weight: 341.428
• Mol file: 878156-25-3.mol

Synonyms:tert-butyl (3-tosyl-cyclobutyl)-carbamate;Toluene-4-sulfonic acid 3-t-butoxycarbonylamino-cyclobutyl ester

Chemical Property of tert-butyl (3-tosyl-cyclobutyl)-carbamate

Chemical Property:

• PSA: 90.08000
• LogP: 4.22770

Purity/Quality:

97% ^*data from raw suppliers

3-((tert-Butoxycarbonyl)amino)cyclobutyl4-methylbenzenesulfonate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (3-tosyl-cyclobutyl)-carbamate

There total 3 articles about tert-butyl (3-tosyl-cyclobutyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate (154748-63-7) + p-toluenesulfonyl chloride (98-59-9) → 3-((tert-butoxycarbonyl)amino)cyclobutyl 4-methylbenzenesulfonate (878156-25-3)

Guidance literature:

With triethylamine; In chloroform; at 0 - 20 ℃; for 2h;

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + tert-butyl 3-hydroxyazetidine-1-carboxylate (141699-55-0) → 3-((tert-butoxycarbonyl)amino)cyclobutyl 4-methylbenzenesulfonate (878156-25-3)

Guidance literature:

tert-butyl 3-hydroxyazetidine-1-carboxylate; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

→ 3-((tert-butoxycarbonyl)amino)cyclobutyl 4-methylbenzenesulfonate (878156-25-3)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 20h;

upstream raw materials:

tert-butyl ((1s,3s)-3-hydroxycyclobutyl)carbamate

p-toluenesulfonyl chloride

tert-butyl 3-hydroxyazetidine-1-carboxylate

Downstream raw materials:

tert-butyl N-[3-(pyrrolidin-1-yl)cyclobutyl]carbamate