(1S, 2S, 5R)-NEOMENTHYL BROMIDE

Base Information

• Chemical Name: (1S, 2S, 5R)-NEOMENTHYL BROMIDE
• CAS No.: 87161-57-7
• Molecular Formula: C10H19Br
• Molecular Weight: 219.165
• Mol file: 87161-57-7.mol

Synonyms:(1S, 2S, 5R)-NEOMENTHYL BROMIDE

Chemical Property of (1S, 2S, 5R)-NEOMENTHYL BROMIDE

Chemical Property:

• PSA: 0.00000
• LogP: 3.84210

Purity/Quality:

(1S,2S,5R)-NEOMENTHYL BROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S, 2S, 5R)-NEOMENTHYL BROMIDE

There total 10 articles about (1S, 2S, 5R)-NEOMENTHYL BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(-)-menthol (2216-51-5) → (1S,2S,4R)-2-bromo-1-isopropyl-4-methylcyclohexane (87161-57-7)

Guidance literature:

With carbon tetrabromide; tris[4-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctyloxy)phenyl]phosphane; In toluene; at 50 ℃; for 4h;

DOI:10.1016/j.tetlet.2003.08.064

Reference yield: 83.0%

2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)tetrahydro-2H-pyran (72020-06-5,80924-03-4,97526-56-2,123121-06-2,128946-28-1,128946-29-2,128946-30-5,128946-31-6,134052-28-1) → (1S,2S,4R)-2-bromo-1-isopropyl-4-methylcyclohexane (87161-57-7)

Guidance literature:

With tetrabutylammomium bromide; dichloromethylenedimethyliminium chloride; In dichloromethane; at 0 ℃;

DOI:10.1016/S0040-4039(97)00677-1

Reference yield: 60.0%

(-)-menthol (2216-51-5) → (1R)-trans-p-menth-2-ene (5113-93-9) + (1S,2S,4R)-2-bromo-1-isopropyl-4-methylcyclohexane (87161-57-7)

Guidance literature:

With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.15h;

DOI:10.3906/kim-1804-41

upstream raw materials:

(-)-menthol

bromo-cyano-triphenyl-phosphorane

menthyl tosylate

2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)tetrahydro-2H-pyran

Downstream raw materials:

(1R,2S,5R)-menthyl chloride

neomenthyl chloride

2-((1R,2R,5R)-2-isopropyl-5-methylcyclohexyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

trans-1,4-menthane