(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3,4-dimethoxybenzoate

Base Information

• Chemical Name: (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3,4-dimethoxybenzoate
• CAS No.: 500-56-1
• Molecular Formula: C17H23 N O4
• Molecular Weight: 305.374
• Hs Code.: 2933990090
• Mol file: 500-56-1.mol

Synonyms:1aH,5aH-Tropan-3a-ol, veratrate (ester) (8CI); Benzoic acid, 3,4-dimethoxy-, 8-methyl-8-azabicyclo[3.2.1]oct-3-ylester, endo-; Convolamine (6CI); Veratric acid, 3a-tropanyl ester (7CI); Convolamin; Convolvamine;O-Methylphyllalbine; Veratroyltropine

Chemical Property of (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3,4-dimethoxybenzoate

Chemical Property:

• Vapor Pressure: 4.08E-07mmHg at 25°C
• Boiling Point: 415.6°Cat760mmHg
• Flash Point: 205.1°C
• PSA: 48.00000
• Density: 1.19g/cm³
• LogP: 2.42370

Purity/Quality:

98%min ^*data from raw suppliers

CONVOLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3,4-dimethoxybenzoate

There total 3 articles about (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3,4-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3,4-dimethoxybenzoic acid chloride (3535-37-3) + 3-tropanol (120-29-6) → 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,4-dimethoxybenzoate (500-56-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0039-1690238

Reference yield:

Veratric acid (93-07-2) → 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,4-dimethoxybenzoate (500-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 5 h / 20 °C

2: triethylamine; dmap / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1055/s-0039-1690238

Reference yield:

convolamine N-oxide → 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,4-dimethoxybenzoate (500-56-1)

Guidance literature:

With zinc; In hydrogenchloride;

DOI:10.1007/BF00714934

upstream raw materials:

3,4-dimethoxybenzoic acid chloride

3-tropanol

Veratric acid

Downstream raw materials:

8-azabicyclo[3.2.1]octan-3-yl 3,4-dimethoxybenzoate