Isoxazolo[4,5-c]pyridin-4(5H)-one, 6,7-dihydro-3,5-dimethyl- (9CI)

Base Information

Chemical Name:Isoxazolo[4,5-c]pyridin-4(5H)-one, 6,7-dihydro-3,5-dimethyl- (9CI)
CAS No.:164223-46-5
Molecular Formula:C₈H₁₀N₂O₂
Molecular Weight:166.18
Hs Code.:
Mol file:164223-46-5.mol

Synonyms:Isoxazolo[4,5-c]pyridin-4(5H)-one, 6,7-dihydro-3,5-dimethyl- (9CI)

Suppliers and Price of Isoxazolo[4,5-c]pyridin-4(5H)-one, 6,7-dihydro-3,5-dimethyl- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Isoxazolo[4,5-c]pyridin-4(5H)-one, 6,7-dihydro-3,5-dimethyl- (9CI)

Chemical Property:

Boiling Point:361.8±42.0 °C(Predicted)
PKA:-2.11±0.20(Predicted)
Density:1.220±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Isoxazolo[4,5-c]pyridin-4(5H)-one, 6,7-dihydro-3,5-dimethyl- (9CI)

There total 5 articles about Isoxazolo[4,5-c]pyridin-4(5H)-one, 6,7-dihydro-3,5-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 164223-42-1
3-Methyl-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridin-4-one

: 74-88-4
methyl iodide

: 164223-46-5
3,5-Dimethyl-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridin-4-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; 1.) -78 deg C, 2 h, 2.) 20 deg C, 1.5 h;

Reference yield:

: 164223-35-2
ethyl 5-{[(benzyloxy)carbonyl]amino}-3-oxopentanoate

: 164223-46-5
3,5-Dimethyl-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / Heating

2: Et₃N, POCl₃ / CHCl₃ / 15 h / Ambient temperature

3: 90 percent / HBr / acetic acid / 4 h / Ambient temperature

4: 96 percent / Na₂CO₃, H₂O / 16 h / Ambient temperature

5: 65 percent / LDA / hexane; tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) 20 deg C, 1.5 h

With water; hydrogen bromide; sodium carbonate; triethylamine; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; hexane; chloroform; acetic acid; toluene;

Reference yield:

: 164223-36-3
Ethyl 5-(2-benzyloxycarbonylaminoethyl)-3-methylisoxazole-4-carboxylate

: 164223-46-5
3,5-Dimethyl-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / HBr / acetic acid / 4 h / Ambient temperature

2: 96 percent / Na₂CO₃, H₂O / 16 h / Ambient temperature

3: 65 percent / LDA / hexane; tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) 20 deg C, 1.5 h

With water; hydrogen bromide; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetic acid;