2-[4-(2-Methylpropoxy)phenyl]acetohydrazide

Base Information

• Chemical Name: 2-[4-(2-Methylpropoxy)phenyl]acetohydrazide
• CAS No.: 61904-59-4
• Molecular Formula: C12H18N2O2
• Molecular Weight: 222.287
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID00492461
• Wikidata: Q82338383
• Mol file: 61904-59-4.mol

Synonyms:2-[4-(2-methylpropoxy)phenyl]acetohydrazide;61904-59-4;2-(4-Isobutoxyphenyl)acetohydrazide;DTXSID00492461;MFCD18157667;AKOS015841799;ME-0232;SB86494;FT-0682737;J-506022

Chemical Property of 2-[4-(2-Methylpropoxy)phenyl]acetohydrazide

Chemical Property:

• PSA: 64.35000
• LogP: 2.34500
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 222.136827821
• Heavy Atom Count: 16
• Complexity: 211

Purity/Quality:

98%min ^*data from raw suppliers

2-[4-(2-Methylpropoxy)phenyl]acetohydrazide >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)COC1=CC=C(C=C1)CC(=O)NN

Technology Process of 2-[4-(2-Methylpropoxy)phenyl]acetohydrazide

There total 4 articles about 2-[4-(2-Methylpropoxy)phenyl]acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(4-Isobutoxy-phenyl)-acetic acid ethyl ester (15560-74-4) → (4-Isobutoxy-phenyl)-acetic acid hydrazide (61904-59-4)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

Reference yield:

4-hydroxyphenylacetate (156-38-7) → (4-Isobutoxy-phenyl)-acetic acid hydrazide (61904-59-4)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 70 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 75 - 80 °C

3: hydrazine hydrate / ethanol / Reflux

With thionyl chloride; hydrazine hydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

(4-hydroxy-phenyl)-acetic acid ethyl ester (17138-28-2) → (4-Isobutoxy-phenyl)-acetic acid hydrazide (61904-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 75 - 80 °C

2: hydrazine hydrate / ethanol / Reflux

With hydrazine hydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

4-hydroxyphenylacetate

(4-hydroxy-phenyl)-acetic acid ethyl ester

(4-Isobutoxy-phenyl)-acetic acid ethyl ester

Downstream raw materials:

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene

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