15560-74-4

Upstream product

• 64-17-5 ethanol 
• 1126-75-6 (isobutyloxy)benzene 
• 75-36-5 acetyl chloride 
• 78-77-3 Isobutyl bromide 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 156-38-7 4-hydroxyphenylacetate 
• 50-00-0 formaldehyd 
• 143-33-9 sodium cyanide 

Downstream Products

• 706779-91-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide 
• 61904-59-4 (4-Isobutoxy-phenyl)-acetic acid hydrazide 

Relevant academic research and scientific papers

Method for continuously preparing pimavanserin by using micro-channel reactor

The invention discloses a method for continuously preparing pimavanserin by using a micro-channel reactor. The method comprises the following steps: dissolving a reaction substrate in an organic solvent, pumping the material solution into a micro-channel reactor by using a feeding pump, sufficiently mixing, and carrying out continuous Curtius rearrangement and addition reaction to obtain the pimavanserin. According to the invention, the micro-channel reactor is adopted for reaction, so that the mixing uniformity is good, the reaction time is shortened, and the operation is simple and safe; andthe environmental pollution is obviously reduced.