5-Bromo-N-[2-(4-morpholinyl)ethyl]-2-pyridinamine

Base Information

• Chemical Name: 5-Bromo-N-[2-(4-morpholinyl)ethyl]-2-pyridinamine
• CAS No.: 364794-56-9
• Molecular Formula: C11H16BrN3O
• Molecular Weight: 286.172
• Hs Code.: 2934999090
• Mol file: 364794-56-9.mol

Synonyms:5-Bromo-N-[2-(4-morpholinyl)ethyl]-2-pyridinamine;5-Bromo-(2-morpholinoethylamino)pyridine;5-Bromo-N-(2-morpholinoethyl)pyridin-2-amine;N-(5-bromo-2-pyridinyl)-4-Morpholineethanamine

Chemical Property of 5-Bromo-N-[2-(4-morpholinyl)ethyl]-2-pyridinamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 403.721°C at 760 mmHg
• Flash Point: 197.964°C
• PSA: 37.39000
• Density: 1.435g/cm³
• LogP: 1.59910
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-(2-morpholinoethylamino)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-N-[2-(4-morpholinyl)ethyl]-2-pyridinamine

There total 1 articles about 5-Bromo-N-[2-(4-morpholinyl)ethyl]-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + 5-bromo-2-fluoropyridine (766-11-0) → (5-bromopyridin-2-yl)-(2-morpholin-4-yl-ethyl)amine (364794-56-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 180 ℃; for 0.333333h; Product distribution / selectivity; microwave irradiation;

Reference yield: 44.0%

(5-bromopyridin-2-yl)-(2-morpholin-4-yl-ethyl)amine (364794-56-9) + 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-N-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide (1267856-03-0) → 2-(4-(6-(2-morpholinoethylamino)pyridin-3-yl)phenyl)-N-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide (1267851-47-7)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 110 ℃; for 4h; Inert atmosphere;

Reference yield:

(5-bromopyridin-2-yl)-(2-morpholin-4-yl-ethyl)amine (364794-56-9) → 4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate (1267851-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

2: ethanol / 2 h / 60 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water;

upstream raw materials:

4-(2-AMINOETHYL)MORPHOLINE

5-bromo-2-fluoropyridine

Downstream raw materials:

2-(4-(6-(2-morpholinoethylamino)pyridin-3-yl)phenyl)-N-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide

4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate