4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

Base Information

Chemical Name:4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate
CAS No.:1267851-48-8
Molecular Formula:CH₄O₃S*C₂₆H₃₀F₃N₅O₃
Molecular Weight:613.658
Hs Code.:

4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

Synonyms:4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

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Chemical Property of 4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

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Technology Process of 4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

There total 4 articles about 4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1267851-47-7
2-(4-(6-(2-morpholinoethylamino)pyridin-3-yl)phenyl)-N-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide

: 1267851-48-8
4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

Guidance literature:: In ethanol; at 60 ℃; for 2h;

Reference yield:

: 766-11-0
5-bromo-2-fluoropyridine

: 1267851-48-8
4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.33 h / 180 °C / microwave irradiation

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

3: ethanol / 2 h / 60 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1267851-48-8
4-(2-(5-(4-(2-oxo-2-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-ylamino)ethyl)morpholin-4-ium methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.33 h / 180 °C / microwave irradiation

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

3: ethanol / 2 h / 60 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide;