2-(triMethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:2-(triMethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:375854-52-7
Molecular Formula:C18H24N2O2Si
Molecular Weight:328.486
Hs Code.:
Mol file:375854-52-7.mol

Synonyms:2-(triMethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Suppliers and Price of 2-(triMethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-(Trimethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 95%
10g
$ 3368.00

Matrix Scientific
2-(Trimethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 95%
5g
$ 1943.00

Crysdot
2-(Trimethylsilyl)ethyl4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 95+%
1g
$ 580.00

Chemenu
2-(Trimethylsilyl)ethyl4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 95%
1g
$ 542.00

Alichem
2-(Trimethylsilyl)ethyl4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
1g
$ 620.60

Total 3 raw suppliers

Chemical Property of 2-(triMethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

PSA：53.33000
LogP:4.06008

Purity/Quality:

95+% ^*data from raw suppliers

2-(Trimethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(triMethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 5 articles about 2-(triMethylsilyl)ethyl 4-(3-cyanophenyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 375854-77-6
2-(trimethylsilyl)ethyl 1,2,3,6-tetrahydro-4-trifluoromethylsulfonyloxy-pyridine-1-carboxylate

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 375854-52-7
2-(trimethylsilanyl)ethyl 4-(3-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; acetonitrile; at 20 ℃; for 3.5h; Heating / reflux;

Reference yield:

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 3-cyanoboronic acid

: 4-oxo-piperidine-1-carboxylic acid (trimethylsilyl)-ethyl ester

: 375854-52-7
2-(trimethylsilanyl)ethyl 4-(3-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: With nitrogen; sodium carbonate; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; n-heptane; dichloromethane; acetonitrile;

Reference yield:

: 181701-30-4
4-oxo-piperidine-1-carboxylic acid 2-(trimethylsilyl)ethyl ester

: 375854-52-7
2-(trimethylsilanyl)ethyl 4-(3-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 22.1 g / lithium hexamethyldisilazide / tetrahydrofuran / 3 h / 0 °C

2: 10.46 g / sodium carbonate; lithium chloride; tetrakistriphenylphosphine palladium⁽⁰⁾ / acetonitrile / 1.5 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2005.02.014