3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride(SALTDATA: FREE)

Base Information

• Chemical Name: 3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride(SALTDATA: FREE)
• CAS No.: 1206117-96-5
• Molecular Formula: C₉H₇ClN₂O₄S
• Molecular Weight: 274.685
• Hs Code.: 2933990090
• Mol file: 1206117-96-5.mol

Synonyms:3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride(SALTDATA: FREE);3-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride;3-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride

Chemical Property of 3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride(SALTDATA: FREE)

Chemical Property:

• PKA: 11.03±0.20(Predicted)
• PSA: 97.64000
• Density: 1.587±0.06 g/cm3(Predicted)
• LogP: 1.64740

Purity/Quality:

99%, ^*data from raw suppliers

3-Methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride(SALTDATA: FREE)

There total 2 articles about 3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methyl-2,4(1H,3H)-quinazolinedione (607-19-2) → 3-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride (1206117-96-5)

Guidance literature:

With chlorosulfonic acid; at 20 - 60 ℃; for 2h;

Reference yield:

2-Amino-N-methylbenzamid (4141-08-6) → 3-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride (1206117-96-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 135 - 145 °C

2: chlorosulfonic acid / 2 h / 20 - 60 °C

With chlorosulfonic acid; In N,N-dimethyl-formamide;

Reference yield:

3-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride (1206117-96-5) → N-(3-hydroxypropyl)-4-[[3-methyl-6-[(1-methylcyclopropyl)sulfamoyl]-2,4-dioxoquinazolin-1-yl]methyl]benzamide

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2.25 h / 34 °C

2: dmap; pyridine / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

4: 1 h / 120 °C / Microwave irradiation

With pyridine; dmap; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

3-methyl-2,4(1H,3H)-quinazolinedione

2-Amino-N-methylbenzamid

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