607-19-2

Basic information

• Product Name: 3-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE
• Synonyms: 3-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione;2,4(1H,3H)-Quinazolinedione, 3-methyl-;3-methyl-1H-quinazoline-2,4-dione;3-methyl-1H-quinazoline-2,4-quinone
• CAS NO: 607-19-2
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.18
• Mol File: 607-19-2.mol
• Article Data: 24

Chemical Properties

• Melting Point: 236-238 °C
• Appearance: /
• Density: 1.292g/cm³
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• PKA: 12.85±0.20(Predicted)
• CAS DataBase Reference: 3-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE(607-19-2)
• EPA Substance Registry System: 3-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE(607-19-2)

Safety Data

• Hazardous Substances Data: 607-19-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 3849, 1988 DOI: 10.1016/S0040-4039(00)82131-0

InChI:InChI=1/C9H8N2O2/c1-11-8(12)6-4-2-3-5-7(6)10-9(11)13/h2-5H,1H3,(H,10,13)

Upstream product

• 57212-70-1 N-(mesyloxy)phthalimide 
• 74-89-5 methylamine 
• 186581-53-3 diazomethane 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 64-17-5 ethanol 
• 2164-95-6 N-phenyl-N'-(2-carboxyphenyl)-urea 
• 530-62-1 1,1'-carbonyldiimidazole 
• 4141-08-6 2-Amino-N-methylbenzamid 
• 1705-09-5 2-mercapto-3-methyl-3,4-dihydroquinazolin-4-one 
• 201230-82-2 carbon monoxide 
• 3400-29-1 N-methyl-2-nitrobenzamide 
• 85-44-9 phthalic anhydride 
• 75-44-5 phosgene 
• 118-48-9 isatoic anhydride 

Downstream Products

• 1206117-96-5 3-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride 
• 1196453-25-4 C₁₆H₁₄N₂O₂S 
• 1196453-29-8 C₁₆H₁₁F₃N₂O₂ 
• 1196453-26-5 C₁₇H₁₇N₃O₂ 
• 1196453-30-1 C₁₆H₁₂N₂O₄ 
• 39602-30-7 1-(4-methoxyphenyl)-3-methylquinazoline-2,4(1H,3H)-dione 
• 607-68-1 2,4-dichloroquinazoline 

Relevant articles and documents

Synthesis and evaluation of highly selective quinazoline-2,4-dione ligands for sphingosine-1-phosphate receptor 2

A series of twenty-nine new quinazoline-2,4-dione compounds were synthesized and their IC50 values for binding toward sphingosine-1-phosphate receptor 2 (S1PR2) were determined using a [32P]S1P binding assay. Seven compounds 2a, 2g, 2h, 2i, 2j, 2k, and 5h exhibit high S1PR2 binding potencies (IC50 values 98%), and high molar activity (153-222 GBq μmol-1, at the end of bombardment). [11C]2a and [11C]2i were further evaluated by the ex vivo biodistribution study. The results showed that both tracers have low brain uptake, preventing their potential for neuroimaging application. Further explorations of this class of S1PR2 PET tracers in peripheral tissue diseases are underway. This journal is

Synthesis of methyl [3-alkyl-2-(2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamido] alkanoate

A series of methyl [3-alkyl-2-(2,4-dioxo-3,4-dihydro-2H-quinazolin-1-yl)-acetamido] alkanoate 10-13a-f has been developed on the basis of the N-chemoselective reaction of 3-substituted quinazoline-2,4-diones 3a-d with ethyl chloroacetate and azide coupling method with amino acid ester hydrochloride. The precursor quinazoline diones 3a-d chemoselective reactions were studied using DFT(B3LYP)/6-311G level of theory and were prepared by a new rearrangement method from the corresponding 2-(3-methyl-4-oxo-3,4- dihydroquinazolin-2-ylthio) acetohydrazide 6. {figure presented}.

Synthesis of 3-methylquinazolin-4(3H)-one derivatives

Oxidation of 3-methyl-2-sulfanylquinazolin-4(3H)-one with chlorine dioxide under different conditions gave 2,2'-disulfanediylbis[3-methylquinazolin-4(3H)- one], 3-methyl-4-oxo-3,4-dihydroquinazoline-2-sulfonic acid, 3-methylquinazoline-2,4(1H,3H)-dione, 6