5-Trimethylstannyl-2'-deoxyuridine

Base Information

• Chemical Name: 5-Trimethylstannyl-2'-deoxyuridine
• CAS No.: 146629-34-7
• Molecular Formula: C12H20N2O5Sn
• Molecular Weight: 391.011
• DSSTox Substance ID: DTXSID80439455
• Wikidata: Q82255407
• Mol file: 146629-34-7.mol

Synonyms:146629-34-7;5-(Trimethylstannyl)-2'-deoxyuridine;5-TRIMETHYLSTANNYL-2'-DEOXYURIDINE;1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-trimethylstannylpyrimidine-2,4-dione;SCHEMBL4276379;DTXSID80439455;OQDVZLNWCJTGNH-OIXZBRQUSA-N;AG-D-91032

Chemical Property of 5-Trimethylstannyl-2'-deoxyuridine

Chemical Property:

• PSA: 104.81000
• LogP: -0.61810
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 392.039424
• Heavy Atom Count: 20
• Complexity: 459

Purity/Quality:

97% ^*data from raw suppliers

5-(Trimethylstannyl)-2''-deoxyuridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Sn](C)(C)C1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
• Isomeric SMILES: C[Sn](C)(C)C1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
• Uses: Several novel 5-substituted 2'-deoxyuridine (dUrd) analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells, and human platelet thymidine (dThd) phosphorylase. Several novel 5-substituted 2''-deoxyuridine (dUrd) analogs were evaluated as substrates for highly purified herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) derived from HSV-1 TK gene-transfected murine mammary carcinoma FM3A cells, and human platelet thymidine (dThd) phosphorylase.

Technology Process of 5-Trimethylstannyl-2'-deoxyuridine

There total 1 articles about 5-Trimethylstannyl-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

methanol (67-56-1) + 5-Iodo-2'-deoxyuridine (54-42-2,162239-35-2) → Na123 I + 5-trimethylstannyl-2'-deoxyuridine (146629-34-7)

Guidance literature:

With hexamethyldistannane; bis(triphenylphosphine)palladium(II) dichloride; In 1,4-dioxane; chloroform;

Reference yield:

5-trimethylstannyl-2'-deoxyuridine (146629-34-7) → 5-Iodo-2'-deoxyuridine (54-42-2,162239-35-2)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; acetic acid; sodium iodide; In chloroform; for 0.00416667h; Irradiation;

DOI:10.1002/jlcr.2580340604

Reference yield:

5-trimethylstannyl-2'-deoxyuridine (146629-34-7) → 5-bromo-2'-deoxyuridine (59-14-3,723-73-9)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; acetic acid; sodium bromide; In chloroform; for 0.00416667h; Irradiation;

DOI:10.1002/jlcr.2580340604

upstream raw materials:

methanol

5-Iodo-2'-deoxyuridine

Downstream raw materials:

5-bromo-2'-deoxyuridine

5-Iodo-2'-deoxyuridine

Refernces