ethyl thieno[2,3-b]pyrazine-6-carboxylate

Base Information

• Chemical Name: ethyl thieno[2,3-b]pyrazine-6-carboxylate
• CAS No.: 59944-77-3
• Molecular Formula: C₉H₈N₂O₂S
• Molecular Weight: 208.241
• Mol file: 59944-77-3.mol

Synonyms:ethyl thieno[2,3-b]pyrazine-6-carboxylate

Chemical Property of ethyl thieno[2,3-b]pyrazine-6-carboxylate

Chemical Property:

• PSA: 80.32000
• LogP: 1.86800

Purity/Quality:

99% ^*data from raw suppliers

Thieno[2,3-b]pyrazine-6-carboxylicAcidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl thieno[2,3-b]pyrazine-6-carboxylate

There total 5 articles about ethyl thieno[2,3-b]pyrazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

<(formyl-2 pyrazinyl-3) thio-2>acetate d'ethyle (74990-46-8) → thieno<2,3-b>pyrazine carboxylate d'ethyle-6 (59944-77-3)

Guidance literature:

With sodium carbonate; In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570170210

Reference yield: 80.0%

ethanol (64-17-5) + thieno[2,3-b]pyrazine-6-carboxylic acid (59944-79-5) → thieno<2,3-b>pyrazine carboxylate d'ethyle-6 (59944-77-3)

Guidance literature:

ethanol; thieno[2,3-b]pyrazine-6-carboxylic acid; With sulfuric acid; at 80 ℃;

With sodium carbonate; In ethanol;

Reference yield:

2-chloro-3-methylpyrazine (95-58-9) → thieno<2,3-b>pyrazine carboxylate d'ethyle-6 (59944-77-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / ethylate de sodium / ethanol / 1.5 h / Heating

2: 40 percent / SeO₂ / dioxane / 6 h / Heating

3: 94 percent / sodium carbonate / ethanol / 2 h / Heating

With selenium(IV) oxide; sodium ethanolate; sodium carbonate; In 1,4-dioxane; ethanol;

DOI:10.1002/jhet.5570170210

upstream raw materials:

ethyl 7-aminothieno[2,3-b]-pyrazine-6-carboxylate

<(formyl-2 pyrazinyl-3) thio-2>acetate d'ethyle

2-chloro-3-methylpyrazine

<(methyl-2 pyrazinyl-3) thio-2>acetate d'ethyle

Downstream raw materials:

3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(thieno[2,3-b]pyrazin-6-ylmethylamino)phenyl)benzamide

thieno<2,3-b>pyrazine

thieno[2,3-b]pyrazine-6-carboxylic acid

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