diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate

Base Information

Chemical Name:diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate
CAS No.:1300031-60-0
Molecular Formula:C20H24N2O6
Molecular Weight:388.42
Hs Code.:

Synonyms:diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate

Suppliers and Price of diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate

Chemical Property:

PSA：99.89000
LogP:3.46200

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate

There total 4 articles about diethyl 2-((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenylamino)methylene)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1300031-61-1
[3-(3,5-dimethyl-4-isoxazolyl)-4-(methyloxy)phenyl]amine

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 1300031-60-0
1,3-diethyl 2-([[3-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methoxyphenyl]amino]methylidene)propanedioate

Guidance literature:: at 130 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.01.125

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1300031-60-0
1,3-diethyl 2-([[3-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methoxyphenyl]amino]methylidene)propanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h

3: 1 h / 130 °C

With palladium on activated charcoal; hydrogen; caesium carbonate; sodium sulfite; In 1,2-dimethoxyethane; ethanol; water; ethyl acetate; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.125

Reference yield:

: 5399-03-1
2-iodo-1-methoxy-4-nitrobenzene

: 1300031-60-0
1,3-diethyl 2-([[3-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methoxyphenyl]amino]methylidene)propanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h

3: 1 h / 130 °C

With palladium on activated charcoal; hydrogen; caesium carbonate; sodium sulfite; In 1,2-dimethoxyethane; ethanol; water; ethyl acetate; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.125