Technology Process of 4-[2-BUTYL-5-(2-METHOXYCARBONYL-3-THIOPHEN-2-YL-PROPENYL)-IMIDAZOL-1-YLMETHYL]-BENZOIC ACID
There total 11 articles about 4-[2-BUTYL-5-(2-METHOXYCARBONYL-3-THIOPHEN-2-YL-PROPENYL)-IMIDAZOL-1-YLMETHYL]-BENZOIC ACID which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydride / 1.) DME, RT, 30 min, 2.) DME, 2.5 h
2: hydrogen / palladium on activated charcoal / ethyl acetate / 18 h / 2585.7 Torr
3: lithium diisopropyl amide / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 5 min
4: dmap / 16 h
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.67 h / 110 °C
6: trifluoroacetic acid / dichloromethane / 5 h / Ambient temperature
With
dmap; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm00065a011
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C
2: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH2Cl2, reflux
3: lithium diisopropyl amide / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 5 min
4: dmap / 16 h
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.67 h / 110 °C
6: trifluoroacetic acid / dichloromethane / 5 h / Ambient temperature
With
dmap; manganese(IV) oxide; hydrogen; potassium acetate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00065a011
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 70 °C
2: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH2Cl2, reflux
3: lithium diisopropyl amide / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 5 min
4: dmap / 16 h
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0.67 h / 110 °C
6: trifluoroacetic acid / dichloromethane / 5 h / Ambient temperature
With
dmap; manganese(IV) oxide; hydrogen; potassium acetate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00065a011
