1-[(1S)-1-(Hydroxymethyl)propyl]-2-pyrrolidinone

Base Information

• Chemical Name: 1-[(1S)-1-(Hydroxymethyl)propyl]-2-pyrrolidinone
• CAS No.: 909566-58-1
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Mol file: 909566-58-1.mol

Synonyms:1-[(1S)-1-(Hydroxymethyl)propyl]-2-pyrrolidinone

Chemical Property of 1-[(1S)-1-(Hydroxymethyl)propyl]-2-pyrrolidinone

Chemical Property:

• PSA: 40.54000
• LogP: 0.31760

Purity/Quality:

95% ^*data from raw suppliers

1-[(1S)-1-(Hydroxymethyl)propyl]-2-pyrrolidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(1S)-1-(Hydroxymethyl)propyl]-2-pyrrolidinone

There total 10 articles about 1-[(1S)-1-(Hydroxymethyl)propyl]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-1-(1-(benzyloxy)butan-2-yl)pyrrolidin-2-one (912643-33-5) → 1-((S)-1-hydroxybutane-2-yl)pyrrolidin-2-one (909566-58-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 6h; under 760 Torr;

DOI:10.1016/j.tetlet.2006.07.061

Reference yield: 95.0%

(S)-2-aminobutan-1-ol (5856-62-2) + 4-Chlorobutanoyl chloride (4635-59-0) → 1-((S)-1-hydroxybutane-2-yl)pyrrolidin-2-one (909566-58-1)

Guidance literature:

With potassium hydroxide; sodium sulfate; In toluene; at 0 - 20 ℃; for 10h;

Reference yield: 92.0%

1-((S)-1-(benzyloxy)but-3-en-2-yl)pyrrolidin-2-one (1105010-94-3) → 1-((S)-1-hydroxybutane-2-yl)pyrrolidin-2-one (909566-58-1)

Guidance literature:

With palladium dihydroxide; hydrogen; In methanol; for 1h;

DOI:10.3987/COM-08-S(N)106

upstream raw materials:

(S)-1-(1-(benzyloxy)butan-2-yl)pyrrolidin-2-one

(S)-2-aminobutan-1-ol

4-Chlorobutanoyl chloride

4-butanolide

Downstream raw materials:

(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid

C₁₈H₂₂F₃NO₄

(R)-2-pyrrolidone-N-butyric acid

levetiracetam

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