(R)-4-(2-PROPENYLOXY)-MANDELONITRILE

Base Information

• Chemical Name: (R)-4-(2-PROPENYLOXY)-MANDELONITRILE
• CAS No.: 153225-88-8
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• Mol file: 153225-88-8.mol

Synonyms:(R)-4-(2-PROPENYLOXY)-MANDELONITRILE

Chemical Property of (R)-4-(2-PROPENYLOXY)-MANDELONITRILE

Chemical Property:

• PSA: 53.25000
• LogP: 1.80838

Purity/Quality:

99% ^*data from raw suppliers

(R)-4-(2-PROPENYLOXY)-MANDELONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-4-(2-PROPENYLOXY)-MANDELONITRILE

There total 3 articles about (R)-4-(2-PROPENYLOXY)-MANDELONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

hydrogen cyanide (74-90-8) + 4-(2-propenyloxy)benzaldehyde (40663-68-1) → 2-hydroxy-2-<4-(2-propenyloxy)phenyl>acetonitrile (153225-88-8)

Guidance literature:

With (3S,6S)-3-((1H-Imidazol-5-yl)methyl)-6-benzylpiperazine-2,5-dione; at -15 ℃; for 36h;

DOI:10.1016/S0957-4166(00)80062-2

Reference yield:

4-(2-propenyloxy)benzaldehyde (40663-68-1) + potassium cyanide (151-50-8) → 2-hydroxy-2-<4-(2-propenyloxy)phenyl>acetonitrile (153225-88-8)

Guidance literature:

With Prunus mume (R)-hydroxynitrile lyase; citrate buffer; In dimethyl sulfoxide; for 0.5h; pH=4.0;

DOI:10.1016/j.tet.2005.08.105

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 2-hydroxy-2-<4-(2-propenyloxy)phenyl>acetonitrile (153225-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. KOH, KI / ethanol / 24 h / Heating

2: 88 percent / cyclo<(S)-Phe-(S)-His> / toluene / 24 h / -10 °C

With potassium hydroxide; Cyclo(histidylphenylalanine); potassium iodide; In ethanol; toluene;

DOI:10.1016/0957-4166(94)80124-X

upstream raw materials:

hydrogen cyanide

4-(2-propenyloxy)benzaldehyde

potassium cyanide

4-hydroxy-benzaldehyde

Downstream raw materials:

(-)-(α)-<<<2-(3,4-dimethoxyphenyl)ethyl>amino>methyl>-(α)-<(1,1-dimethylethyl)dimethylsilyloxy>-4-(2-propenyloxy)benzenemethane

(-)-(α)-<<<2-(3,4-dimethoxyphenyl)ethyl>amino>methyl>-4-(2-propenyloxy)benzenemethanol

denopamine

(R)-2-<(1,1-dimethylethyl)dimethylsilyloxy>-2-<4-(2-propenyloxy)phenyl>acetonitrile